23- 159 - LEPROSY

Question 1

Causative agent of lucio leprosy

Answer 1

mycobacterium lepromatosis

Question 2

What is triple lewis response

Answer 2

Dilation of blood capillaries as a secondary axon reflex erythema, which is dependent on nerve integrity, may be tested using a 1:1000 histamine solution, injected intradermally in normal and lesional skin. Within 5 to 10 seconds, erythema will result from the direct action of histamine on the capillaries, causing vasodilation in both areas, normal and lesional. Two minutes after this a secondary erythema caused by capillary dilation will occur only on normal skin. The last phase of triple Lewis response is exudation of liquid to the dermis, resulting in wheal formation in both areas. Therefore, the triple Lewis response is incomplete only on lesional skin, with the absence of secondary erythema.