20 - 119: CUTANEOUS LYMPHOMA

Question 1

MC type of MF present in children with color

Answer 1

Hypopigmented MF

Question 2

Independent prognostic markers for survival, except

a. >60 years old
b. large cell transformation
c. increased LDH
d. decreased LDH

Answer 2

c. increased LDH

Question 3

Characterized by patches, plaques and hair loss within lesions

Answer 3

Folliculotrophic MF

Question 4

Solitary hyperkeratotic plaque on an extremitiy

Answer 4

Woringer-Kolopp disease – AKA pagetoid reticulosis

Question 5

Localized areas of bulky folding of the skin on the axillae and groins

Answer 5

Granulomatous slack skin

Question 6

T cell subtype present in Pagetoid reticulosis

Answer 6

CD8

Question 7

Sezary syndrome criteria except

a. >100/mm3 sezary cells in the blood – dapar >1000
b. CD4:CD8 ratio >10
c. loss of T cell antigens
d. loss of CD7 and CD26

Answer 7

a. >100/mm3 sezary cells in the blood – dapat >1000

Question 8

Lymphomatoid papulosis: wedged shape infiltrate with >75% large lymphocytes

Answer 8

Type A

Question 9

Lymphomatoid papulosis: angioinvasive/angiocentric type

Answer 9

Type E

Question 10

Lymphomatoid papulosis: mimics primary cutaneous aggressive epidermotropic CD8 cytotoxic TCL

Answer 10

Type D

Question 11

This is defined as neoplasm of clonal centrocytes and centroblasts with or without formation of follicles. Usually presents with solitary or grouped firm, painless, erythematous plaques and tumors.

Answer 11

Primary cutaneous follicular center lymphoma

Question 12

B-lymphocytes-derived malignancies that develop on the skin without extracutaneous involvement at the time of diagnosis and account for 20-25% of primary cutaneous lymphomas.

Answer 12

Primary cutaneous B-cell lymphoma

Question 13

Patients have small red-to-violaceous papules, plaques, or nodules. Seen most commonly on the upper extremities, or the trunk.

Answer 13

Extranodal marginal zone B-cell lymphoma

Question 14

Identified as a distinct clinical entity because of its perceived poor outcome compared with the indolent subtypes. Typically presents as solitary or clustered bluish erythematous plaques and tumors located on one or both legs.

Answer 14

Primary cutaneous diffuse large B-cell lymphoma, leg type

Question 15

First line therapy for primary cutaneous diffuse large B-cell lymphoma, Leg Type.

a. Rituximab
b. Cyclophosphamide
c. Hydroxydaunorubicin
d. Oncovin
e. Prednisolone
f. All
g. a and b

Answer 15

F. ALL