10 - 69 - RELAPSING POLYCHONDRITIS Flashcards
The mean age (range) at diagnosis in men was ___ years and in women ___ years
men: 55 yrs
women: 51 yrs
most frequent manifestation of replapsing polychondritis
Auricular chondritis
causing pain, redness, and swelling of the cartilaginous portion of the pinna, sparing the noncartilaginous lobe
what area is spared in relapsing polychondritis
earlobe
risk factors associated with myelodysplasia
the frequency of dermatologic manifestations (>90%), age at first chondritis, and male-to-female ratio seems higher when RP is associated with myelodysplasia
Most common ocular manifestation
Episcleritis and scleritis
T/F Sensorineural hearing loss is secondary to stenosis of the external auditory canal, eustachian tube chondritis, or serous otitis media,
False
Conductive hearing loss
triggering events of RP
Triggering events of RP include mechanical stimuli such as traumas and piercing
*
diagnostic criteria for RP
may be useful for patients with mild auricular or nasal chondritis, arthralgia, or mild arthritis
Nonsteroidal antiinflammatory drugs, colchicine, or dapsone
oral steroid dose for RP
oral corticosteroids in dose of 0.3 to 1 mg/kg of body weight
prescribed for acute airway obstruction, sudden hearing loss, and/or before surgical intervention (tracheostomy, aortic aneurysm repair, cardiac valve replacement
Pulse intravenous steroids
other therapeutic options for RP
Methotrexate (0.3 mg/kg/week) is often effective. Cyclophosphamide is used in severe forms of RP. Azathioprine, mycophenolate mofetil, cyclosporine, leflunomide, and chlorambucil have produced inconsistent effects.
Infliximab, rituxmab, tocilizumab, anakinra, etanercept, adalimumab, and certolizumab
In a few patients with refractory severe RP, treatment intensification followed by autologous stem cell transplantation has been performed
