2.10 Tissue Level of Organisation - Epithelial; Connective; Muscle; Nervous Tissues Flashcards
Epithilium classification: number of layers
One layer: simple
>1 layers: stratified
Epithilium classification: cell shape on apical surface
Flat: squamous
Cube-like: Cuboidal
Column-like: Columnal
Common function of simple squamous epithilium
- Lines blood vessels and air sacs of lungs
- Permits exchange of nutrients, wastes, and gases
Common function of simple cuboidal epithilium
- Lines kidney tubules and glands
- Secretes and reabsorbs water and small molecules
Common function of Simple columnar epithilium. Therefore, where would it commonly be located?
- Lines most digestive organs
- Absorbs nutrients, produces mucus (have microvilli)
Common function of stratified squamous epithilium
- Outer layer of skin, mouth, vagina
- Protects against abrasion, drying out, infection
Common function of stratified cuboidal epithilium
- Lines ducts of sweat glands
- Secretes water and ions
Common function of stratified/psuedostratified columnar epithilium
- Lines epididymus, mammary glands, larynx
- Secretes mucus
What are the two types of epithelium?
- Surface: covers and lines the inside and outside surfaces of the body
- Glandular: produces a secretion
What type of epithelium is endothelium? What is its function?
- Simple squamous
- It is found in the cardiovascular and lymphatic system, since its smooth internal structure allows flow of fluids. It’s thinness allows for easy exchange of substances.
What type of epithelium is mesothelium? What is it’s function?
-Simple squamous, with thicker layer of connective tissue than endothelium.
- It is a lubricated surface, and is located in our pleura, decreasing the friction between our lungs and rib cage.
Non-keratinized stratified squamous epithelium
- Protective layer
- Moist surface, lines mouth, oesophagus, nose, vagina etc.
Keratinized stratified squamous epithelium
Like non-keratinized stratified squamous epithelium, except with a layer of dead, anucleate cells in superficial layers. This surface is tough, and resistant to tearing.
Pseudostratified columnar ciliated epithelium with goblet cells
- Nuclei on different levels, but all attached to basement membrane (hence psuedo-)
- Goblet cells secrete mucus
- Cilia filter pathogens and other shit upwards via a muco-cilliary escalator, where it can be swallowed or coughed out.
Transitional epithelium
Can change shape
- Stretched: stratified squamous
- Relaxed: stratified cuboidal
Location: ureters and bladder (makes sense; stretching is required)
How are glands formed?
Congregation and subsequent invagination of glandular epithelial cells. Connective support tissues will then grow around it.
What are the two destinations of exocrine gland secretion?
- Into the lumen of an organ
- Directly released onto epithelial cell (e.g. sweat)
What is the function of connective tissue? What properties allow it to do this?
- Provide support and function to the body (tensile and strong)
- Binds tissues and organs (flexible)
- Facilitates communication (Forms a communication network)
What is the extracellular matrix of connective tissue made of?
- Ground substance (viscous, fluid-like)
- Fibres
What are the three types of fibres in the extracellular matrix of connective tissue?
- Collagen
- Elastic
- Reticular
What is the main defining feature of connective tissue?
Extracellular matrix
What are the three classifications of connective tissue
- Connective tissue proper
- Fluid connective tissues
- Supporting connective tissues
What different types of connective tissue structures enable it to provide mechanical support and protection?
- Skeleton (structure and support)
- Skin (support)
- Fat (insulation, cushioning)
What are three other functions of connective tissue?
- Energy storage
- Immunity (carrying immune cells in blood)
- Repair
How does connective tissue provide a framework for communication?
Terconnected “highway” for messenger molecules, gases, nutrients, and waste.
What are the two types of connective tissue proper?
- Loose
- Dense
What are the two types of fluid connective tissue?
- Blood
- Lymph
What are the two types of supporting connective tissue?
- Cartilage
- Bone
How is loose connective tissue defined?
Predominantly made of ground substance. Less fibres.
How is dense connective tissue defined?
Predominantly made of fibres, less ground substance.
What are the two classifications of dense connective tissue?
- Regular (parallel fibres)
- Irregular (not parallel lines)
Function and location of dense regular connective tissue
Function:
- Attach muscle to bone and bone to bone to allow for the transmission of force.
Location:
- Ligaments (B2B) and tendons (M2B)
Function and location of dense irregular connective tissue
Function:
- Protect and encapsulate organs. Can absorb force from multiple directions.
Location:
- Dermis of skin
- Capsules around organs
Function and location of loose connective tissue
Function:
- Nourishment and cushioning
- Allows passageway for blood vessels (and therefore immune defence) and nerves
Location:
- Underlying all epithilia
- Sheaths muscles
- Pleural and pericardal sacs
What is the function of ground substance
- Structural and biochemical support of cells
- Regulates transport of substances (and therefore communication), including gases, waste and nutrients
True or false: ground substance is amorphous (no shape
True
How is ground substance secreted? What is the main component of ground substance?
Secreted mainly by fibroblasts. Mostly made of water.
Why does it matter that ground substance varies in viscosity?
- Determines how easily bacteria or other microbes can penetrate into the extracellular environment of the CT
How does swelling relate to connective tissue?
Swelling occurs due to abnormal accumulation of interstitial fluid in the ground substance of CT
How is elastin different from collagen? How do the effects of elastin change with time?
- Not as strong
- Allows for coiling and recoiling, providing flexibility and elasticity
- Elasticity diminishes with age
What structures do elastic fibres make up
- Skin
- Arteries
- Bronchi
How are reticular fibres different from collagen?
- Thinner and not as strong (inelastic like collagen)
- Allow formation of flexible network/framework
What structures do reticular fibres support?
- Spleen
- Liver
What are the three types of connective tissue cells?
- Structural and storage
- Defense
- Reserve
What are the types of structural and storage cells in connective tissue?
- Fibroblasts (secrete ground substance)
- Fat cells
What are the types of defence cells in connective tissue?
- Marcophages
- Leukocytes (migrating from blood)
- Plasma cells
What are the reserve cells in connective tissue?
Stem cells
What is the most common cell in connective tissue?
Fibroblasts
Activity/function of fibroblasts
- Very metabolically active
- Make fibres and ground substance
- Respond to injury by dividing and secreting collagen (scar tissue)
Structure and function of adipocytes
- Source of energy (fat storage)
- When aggregated, form shock absorbers (e.g. soles of feet, palms of hand)
- White and brown fat
Where are leukocytes made?
- Bone marrow
What are some types of leukocytes?
- Neutrophils
- Lymphocytes
- Eosinophils
What is the role of plasma cell? How does this affect their rate of metabolic activity?
- Antibody secretion
- Very metabolically active
What is the role of mast cells?
- Allergic reactions
- Release histamine
Culprits of hay fever
What happens when histamine is released?
- Vasodilation
- Increased mucous production
Why is muscle tissue considered excitable?
It can propagate electrical signals. (also contractile)
What is another name for muscle cells?
Myocytes
What structures allow muscle fibres/cells to contract?
Microfilaments
How do muscle cells get their blood supply
Connective tissue between muscle fibres
What are the three main types of muscle?
- Skeletal
- Cardiac
- Smooth Muscle
Why are skeletal muscles multi-nucleated?
During development, multiple myoblasts come together to form fully differentiated myocytes, which therefore have multiple nuclei.
What are the shape of skeletal muscle cells?
Large and cylindrical (think of contraction)
What causes visible striations on myocytes?
Overlapping of microfilaments
Why do cardiac muscle cells look like one continuous cell?
They are long cells joined by intercalated discs
Is the nucleus of a cardiac muscle cell centralised or peripheral?
Centralised
Why does it make sense that cardiac muscle are connected by intercalated discs?
Contraction of the heart must be coordinated
Which type of muscle tissue has no striations?
Smooth muscle
What are the cytoplasmic extensions of a nerve cell?
- Dendrites
- Axons
What are neuroglial cells?
Neural support cells (glia: latin -> glue)
What are the three key properties of neurons?
- Excitability (detect stimuli)
- Conductivity (generate propagate signal)
- Secretory (release chemicals for intercellular communication)
Which three ways can neurons communicate with other cells?
- Neuron-neuron
- Neuron-muscle
- Neuron-gland