10.3 Cells and Tissues of the Immune System Flashcards
Which two lineages can haematopoietic stem cells delineate into?
- Myeloid
- Lymphoid
Draw a diagram of lymphoid progenitor differentiation
Where are T cells made? Where do they mature?
Made in bone marrow; matured in thymus. (Both B and T cells are made in the bone marrow)
What cells do granulocytes differentiate from? List three types of granulocytes
- Arise from common myeloid progenitor
- Granulocytes are BEN (basophils, eosinophils, neutrophils)
What type of invader are esoinophils good at fighting against?
Parasites
Other than granulocytes, what three other cell types can myeloid progenitor cells become?
- Megakaryocyte (what do they become?)
- Erthryoblast (what do they become?)
- Monocyte (what do they become?)
Can monocytes only differentiate exclusively into macrophages when they move into tissue?
No: they can also become dendritic cells
List some primary lymphoid organs
- Bone marrow
- Thymus
What is the purpose of B and T cell “education”?
Eliminate B and T cells that recognises self (prevents autoimmunity)
Where do mature lymphocytes reside?
Peripheral lymph tissues
What occurs at secondary lymphoid organs?
MATURE lymphocytes:
- Encounter antigens
- Differentiate into effector cells
What are the two secondary lymphoid organs?
- Spleen
- Lymph nodes
What type of antigens do lymph nodes filter?
Tissue-borne antigens
What types of antigens does the spleen filter?
Blood-borne antigens
What tissue filters mucosal-borne antigenbs?
Mucosal-associated lymphoid tissue (MALT)
