Thyroid and AntiThyroid Drugs

Question 1

Used for the symptomatic treatment of thyrotoxicosis by blocking cardiac adverse effects

Answer 1

Beta-blockers such as propranolol and esmolol

Question 2

Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and indicated for pregnant women in 1st trimester

Answer 2

Propylthiouracil (PTU)

Question 3

Thioamide agents used in hyperthyroidism

Answer 3

Methimazole and propylthiouracil (PTU)

Question 4

Propylthiouracil (PTU) mechanism of action

Answer 4

Inhibits thyroid peroxidase

Question 5

Permanently cures thyrotoxicosis, patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy

Answer 5

Radioactive iodine

Question 6

Can be effective for short term therapy of thyroid storm, but after several weeks of therapy causes an exacerbation of hyperthyroidism

Answer 6

Iodide salts (potassium iodide)

Question 7

Anti-thyroid drugs

Answer 7

Thioamides (methimazole, propylthiouracil), potassium iodide, radioactive iodine (131I)

Question 8

An isomer of T3 which may be used in myxedema coma

Answer 8

Liothyronine (T3)

Question 9

Agent of choice for the treatment of hypothyroidism

Answer 9

Levothyroxine (T4)