Metabolism

Question 1

Constant percentage of drug metabolized per unit time

Answer 1

First order kinetics

Question 2

Name 3 Phase II conjugation reactions

Answer 2

Glucuronidation, acetylation, glutathione conjugation, glycine conjugation, sulfation, methylation, water conjugation

Question 3

Barbiturates, phenytoin, carbamazepine, and rifampin all do this

Answer 3

Induce CYP450

Question 4

Cimetidine, ketoconazole, isoniazid, and grapefruit all do this

Answer 4

Inhibit CYP450

Question 5

Target plasma concentration times (volume of distribution divided by bioavailability)

Answer 5

Loading dose (Cp*(Vd/F))

Question 6

Different steps of Phase I

Answer 6

Oxidation, reduction, hydrolysis

Question 7

Constant amount of drug metabolized per unit time

Answer 7

Zero order kinetics

Question 8

Concentration in the plasma times (clearance divided by bioavailability)

Answer 8

Maintenance dose (Cp*(CL/F))