Antihyperlipidemics

Question 1

SE of HMG COA reductase inhibitors

Answer 1

Rhabdomyolysis and Hepatotoxicity

Question 2

Concurrent use of fibrates and statins increases risk of

Answer 2

Rhabdomyolysis

Question 3

HMG CoA reductase inhibitors are contraindicated in

Answer 3

Pregnancy

Question 4

Fibrates are contraindicated in

Answer 4

Pregnancy

Question 5

Decreases liver triglycerol synthesis

Answer 5

Niacin

Question 6

Most common SE of fibrates

Answer 6

Nausea

Question 7

Fibrates (gemfibrozil) increase activity of

Answer 7

Lipoprotein lipase

Question 8

Monitoring parameter to obtain before initiation of STATINS

Answer 8

LFT’s

Question 9

MOA of lovastatin (STATIN)

Answer 9

inhibits HMG COA reductase

Question 10

How drug or foods (grapefruit juice) increase statin effect

Answer 10

Inhibit Cytochrome P450 3A4

Question 11

Major nutritional side effect of bile acid-binding resins

Answer 11

Impair absorption of fat soluble vitamin absorption (A,D,E,K)

Question 12

Class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins

Answer 12

Ezetimibe (Zetia)

Question 13

SE of niacin

Answer 13

Cutaneous flush

Question 14

Cholestyramine and colestipol are

Answer 14

Bile acid-binding resins

Question 15

Decrease intestinal absorption of cholesterol

Answer 15

Bile acid-binding resins

Question 16

Cutaneous flush due to niacin can be reduced by pretreatment with

Answer 16

Aspirin