Basic Pharmacokinetics Flashcards
1
Q
The fraction of unchanged drug that reaches systemic circulation after administration
A
Bioavailability (F)
2
Q
The ratio of the rate of elimination of a drug to its plasma concentration
A
Clearance (CL)
3
Q
Plasma concentration of a drug at a given time
A
Cp
4
Q
The elimination of drug that occurs before it reaches the systemic circulation
A
First pass effect
5
Q
Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs)
A
Half-life (T1/2)
6
Q
When the rate of drug input equals the rate of drug elimination
A
Steady state
7
Q
Relates the amount of drug in the body to the plasma concentration
A
Volume of distribution (VD)
