Gonadal Hormones and Inhibitors

Question 1

Antiestrogen drugs used for fertility and breast cancer respectively

Answer 1

Clomiphene and tamoxifen

Question 2

Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)

Answer 2

Combination oral contraceptives (OC)

Question 3

Anti-androgen used for hirsutism in females

Answer 3

Cyproterone acetate

Question 4

Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy

Answer 4

Diethylstilbestrol (DES)

Question 5

Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss

Answer 5

Estrogen

Question 6

Estrogen mostly used in oral contraceptives (OC)

Answer 6

Ethinyl estradiol and mestranol

Question 7

5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness

Answer 7

Finasteride (Proscar and Propecia respectively)

Question 8

Common SE of tamoxifen and raloxifene

Answer 8

Hot flashes

Question 9

Anti-progesterone used as abortifacient

Answer 9

Mifepristone (RU-486)

Question 10

Anabolic steroid that has potential for abuse

Answer 10

Nandrolone and stanozolol

Question 11

Oral contraceptive available in a transdermal patch

Answer 11

Ortho-Evra

Question 12

Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study)

Answer 12

Raloxifene

Question 13

Converted to more active form DHT by 5 alpha-reductase

Answer 13

Testosterone