Antiseizure Drugs

Question 1

Q

Answer 1

A

Question 2

Drugs of choice for generalized tonic-clonic and partial seizures

Answer 2

Valproic acid, Phenytoin and Carbamazepine

Question 3

Anti-seizure drugs used also for bipolar affective disorder (BAD)

Answer 3

Valproic acid, carbamazepine, phenytoin and gabapentin

Question 4

Drug of choice for myoclonic seizures

Answer 4

Valproic acid

Question 5

Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress

Answer 5

Valproic acid

Question 6

SE for Lamotrigine

Answer 6

Stevens-Johnson syndrome

Question 7

Mechanisms of action for Phenytoin, Carbamazepine, Lamotrigine

Answer 7

Sodium blockade

Question 8

Laboratory value required to be monitored for patients on valproic acid

Answer 8

Serum ammonia and LFT’s

Question 9

Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism

Answer 9

Phenytoin

Question 10

DOC for febrile seizures

Answer 10

Phenobarbital

Question 11

Drugs of choice for status epilepticus

Answer 11

IV diazepam (or lorazapam) followed by phenytoin

Question 12

Most frequent route of metabolism

Answer 12

Hepatic enzymes

Question 13

SE of phenytoin

Answer 13

Gingival hyperplasia, nystagmus, diplopia and ataxia

Question 14

Anti-seizure drugs used also for pain of neuropathic orgin

Answer 14

Gabapentin

Question 15

MOA for benzodiazepines and barbiturates

Answer 15

GABA-related targets

Question 16

Drugs of choice for absence seizures

Answer 16

Ethosuximide and valproic acid

Question 17

Drugs that can be used for infantile spasms

Answer 17

Corticosteroids

Question 18

Anti-seizure drugs used as alternative drugs for mood stabilization

Answer 18

Carbamazepine, gabapentin, lamotrigine, and valproic acid

Question 19

Anti-seizure drugs used also for Trigeminal neuralgia

Answer 19

Carbamazepine

Question 20

Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida

Answer 20

Carbamazepine

Question 21

MOA for Ethosuximide

Answer 21

Calcium channels

Question 22

SE for Felbamate

Answer 22

Aplastic anemia and acute hepatic failure

Question 23

Carbamazepine may cause

Answer 23

Agranulocytosis

Question 24

MOA for Valproic acid at high doses

Answer 24

Affect calcium, potassium, and sodium channels

Question 25

Anti-seizure medication also used in the prevention of migraines

Answer 25

Valproic acid