Alcohols

Question 1

Agent that is teratogen and causes a fetal syndrome

Answer 1

Alcohol

Question 2

Rate limiting step of alcohol metabolism

Answer 2

Aldehyde dehydrogenase

Question 3

Enzyme that metabolizes acetaldehyde to acetate

Answer 3

Aldehyde dehydrogenase

Question 4

Agent used in the treatment of alcoholism, if alcohol is consumed concurrently, acetaldehyde builds up and results in nausea, headache, flushing, and hypotension

Answer 4

Disulfiram

Question 5

Agents that inhibit aldehyde dehydrogenase

Answer 5

Disulfiram, metronidazole, certain sulfonylureas and cephalosporins

Question 6

Agent that competes for alcohol dehydrogenase in the case of methanol overdose

Answer 6

Ethanol

Question 7

Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS)

Answer 7

Ethanol

Question 8

Agent with zero-order kinetics

Answer 8

Ethanol, theophylline, tolbutamide, warfarin, aspirin, phenytoin

Question 9

Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure

Answer 9

Fomepizole

Question 10

System that increases in activity with chronic exposure and may contribute to tolerance

Answer 10

Microsomal ethanol oxidizing system MEOS

Question 11

The most common neurologic abnormality in chronic alcoholics

Answer 11

Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI)