Pharmacodynamics

Question 1

Strength of interaction between drug and its receptor

Answer 1

Affinity

Question 2

Ability of drug to produce the maximal biologic effect

Answer 2

Efficacy

Question 3

Amount of drug necessary to elicit a biologic effect compared with another drug

Answer 3

Potency

Question 4

Selectivity of a drug for its receptor

Answer 4

Specificity

Question 5

Ability of a drug to produce maximal response after binding to the receptor

Answer 5

Full agonist

Question 6

Ability to produce less than maximal response after binding to the receptor

Answer 6

Partial agonist

Question 7

Ability to bind reversibly to the same site as the drug and without activating the effector system

Answer 7

Competitive antagonist

Question 8

Ability to bind irreversibly to the active site or bind to a site distinctly separate from the agonist binding site

Answer 8

Noncompetitive antagonist

Question 9

Mechanism of action (MOA) utilizes intracellular receptors

Answer 9

Steroid and hormones

Question 10

Mechanism of action (MOA) utilizes transmembrane receptors that have intrinsic enzymatic activity

Answer 10

Insulin, EGF, TGFbeta, PDGF, ANP

Question 11

Mechanism of action (MOA) utilizes ligand gated ion channels

Answer 11

Acetylcholine, nicotine

Question 12

Dose which produces therapeutic response in 50% of the poopulation

Answer 12

ED50

Question 13

Dose which is toxic in 50% of the population

Answer 13

TD50

Question 14

Dose which is lethal to 50% of the population

Answer 14

LD50

Question 15

Window between therapeutic effect and toxic effect

Answer 15

Therapeutic index

Question 16

Drugs that have a high margin of safety is indicated by

Answer 16

High therapeutic index

Question 17

Drugs that have a narrow margin of safety is indicated by

Answer 17

Low therapeutic index