Cholinoreceptor Act and Cholinoresterase Inhibitors

Question 1

Treatment of muscarinic symptoms in organophosphate overdose

Answer 1

Atropine

Question 2

This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention

Answer 2

Bethanechol

Question 3

Toxicity of cholinergics

Answer 3

DUMBELSS - diarrhea, urination, miosis, bronchoconstriction, excitation of skeletal muscle and CNS, lacrimation, salivation, and sweating

Question 4

Antiglaucoma organophosphate, indicated but not used much clinically anymore due to long duration of action

Answer 4

Echothiophate

Question 5

Indirect-Acting ACh Agonist, alcohol, short DOA and used in diagnosis of myasthenia gravis

Answer 5

Edrophonium

Question 6

Insecticide organophosphate

Answer 6

Malathion, parathion

Question 7

Carbamate with intermediate action and used as off-label for postoperative paralytic ileus and urinary retention

Answer 7

Neostigmine

Question 8

Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect, which may lead to convulsions

Answer 8

Physostigmine

Question 9

Muscarinic that is very lipid soluble and used in glaucoma

Answer 9

Pilocarpine

Question 10

Muscarinic used to treat dry mouth in Sjögren’s syndrome

Answer 10

Pilocarpine or Cevimeline

Question 11

This agent competes for phosphorylated cholinesterase enzyme and regenerates enzyme if organophosphate-enzymes complex has not “aged”

Answer 11

Pralidoxime

Question 12

Treatment of myasthenia gravis and sometimes used prophylactically for organophosphate poisoning in chemical warfare

Answer 12

Pyridostigmine

Question 13

The most important cause of acute deaths in cholinesterase inhibitor toxicity

Answer 13

Respiratory failure