Antidepressants

Question 1

Antidepressant having stimulant effects similar to SSRI’s and can increase blood pressure

Answer 1

Venlafaxine

Question 2

Antidepressant inhibiting norepinephrine, serotonin, and dopamine reuptake

Answer 2

Venlafaxine

Question 3

Sedation is a common side effect of these drugs, they lower seizure threshold, uses include BAD, acute panic attacks, phobias, enuresis, and chronic pain and their overdose can be deadly

Answer 3

Tricyclic antidepressants (TCA)

Question 4

Antidepressant also used for sleep that causes priapism

Answer 4

Trazodone

Question 5

Agents having higher sedation and antimuscarinic effects than other TCA’s

Answer 5

Tertiary amines

Question 6

Well-tolerated and are first-line antidepressants

Answer 6

SSRI’s, bupropion, and venlafaxine

Question 7

All antidepressants have roughly the same efficacy in treating depression, agents are chosen based on these criterion

Answer 7

Side-effect profile and prior pt response

Question 8

MAOI should not be administered with SSRI’s or potent TCA’s due to development of this condition

Answer 8

Serotonin syndrome

Question 9

Some of SSRIs’ therapeutic effects beside depression

Answer 9

Panic attacks, social phobias, bulimia nervosa, and PMDD premenstrual dysphoric disorder), OCD

Question 10

Secondary amines that have less sedation and more excitation effect

Answer 10

Nortriptyline, Desipramine

Question 11

Neurotransmitters affected by the action of antidepressants

Answer 11

Norepinephrine and serotonin

Question 12

Antidepressant which is inhibitor of CYP450 enzymes and may be associated with hepatic failure

Answer 12

Nefazodone

Question 13

Most useful in patients with significant anxiety, phobic features, hypochondriasis, and resistant depression

Answer 13

Monamine oxidase inhibitors

Question 14

Antidepressant with MOA as alpha 2 antagonist, has effects on both 5-HT and NE, blocks histamine receptors, and is sedating

Answer 14

Mirtazapine

Question 15

Antidepressant associated with seizures and cardiotoxicity

Answer 15

Maprotiline

Question 16

SE of mirtazapine

Answer 16

Liver toxicity, increased serum cholesterol

Question 17

TCA used in chronic pain, enuresis, and OCD

Answer 17

Imipramine

Question 18

Condition will result from in combination of MAOI with tyramine containing foods (ex. wine, cheese, and pickled meats)

Answer 18

Hypertensive crisis

Question 19

SSRI indicated for premenstrual dysphoric disorder

Answer 19

Fluoxetine (Sarafem)

Question 20

SSRI with long T1/2 and can be administered once weekly for maintenance, not acute tx

Answer 20

Fluoxetine

Question 21

SSRI’s less likely to cause a withdrawal syndrome

Answer 21

Fluoxetine

Question 22

Population group especially sensitive to side effects of antidepressants

Answer 22

Elderly patients

Question 23

TCA with greatest sedation of this group, and marked antimuscarinic effects, used for sleep

Answer 23

Doxepin

Question 24

Three C’s associated with TCA toxicity

Answer 24

Coma, Convulsions, Cardiac problems (arrhythmias and wide QRS)

Question 25

Example of three antidepressants that are indicated for obsessive compulsive disorder

Answer 25

Clomipramine, fluoxetine and fluvoxamine

Question 26

TCA used in obsessive compulsive disorder (OCD), most significant of TCA’s for risk of seizure, weight gain, and neuropsychiatric signs and symptoms

Answer 26

Clomipramine

Question 27

Except for these agents all SSRI have significant inhibition of CytP450 enzymes

Answer 27

Citalopram and its metabolite escitalopram

Question 28

Unicyclic antidepressant least likely to affect sexual performance, used for management of nicotine withdrawal, SE’s include dizziness, dry mouth, aggravation of psychosis, and seizures

Answer 28

Bupropion

Question 29

Antidepressant associated with neuroleptic malignant syndrome

Answer 29

Amoxapine

Question 30

TCA used in chronic pain, a hypnotic, and has marked antimuscarinic effects

Answer 30

Amitriptyline

Question 31

Usual time needed for full effect of antidepressant therapy

Answer 31

2 to 3 weeks