Cancer Chemo

Question 1

Microtubule inhibitor that causes peripheral neuropathy, foot drop (eg. ataxia), and “pins and needles” sensation

Answer 1

Vincristine

Question 2

Anti-estrogen used for estrogen receptor + breast cancer

Answer 2

Tamoxifen

Question 3

Side effect of Mitomycin

Answer 3

SEVERE myelosuppression

Question 4

Toxic effect of anticancer drug can be lessened by rescue agents

Answer 4

Rescue therapy

Question 5

Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously

Answer 5

Pulse therapy

Question 6

Alkylating agent that produces disulfiram-like reaction with ethanol

Answer 6

Procarbazine

Question 7

Drug used in cancer therapy causes Cushing-like symptoms

Answer 7

Prednisone

Question 8

Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest

Answer 8

Paclitaxel (taxol)

Question 9

Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist

Answer 9

Odansetron, granisetron, dolasetron, palonosetron

Question 10

Common toxicities of cisplatin

Answer 10

Nephro and ototoxicity

Question 11

MOPP regimen used in Hodgkin’s disease (HD)

Answer 11

Mechlorethamine+ oncovorin (vincristine)+ procarbazine, and prednisone

Question 12

Alkylating agent, vesicant that causes tissue damage with extravasation

Answer 12

Mechlorethamine

Question 13

Constant proportion of cell population killed rather than a constant number

Answer 13

Log-kill hypothesis

Question 14

Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)

Answer 14

L-asparaginase

Question 15

Used for hairy cell leukemia; it stimulates NK cells

Answer 15

Interferon alpha

Question 16

Prevention of cyclophosphamide induced hemorrhagic cystitis

Answer 16

Hydration and mercaptoethanesulfonate (MESNA)

Question 17

Anti-androgen used for prostate cancer

Answer 17

Flutamide (Eulexin)

Question 18

May protect against doxorubicin cardio-toxicity by chelating iron

Answer 18

Dexrazoxane

Question 19

Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis

Answer 19

Cyclophosphamide

Question 20

Regimen used for breast cancer

Answer 20

CMF (cyclophosphamide, methotrexate, and fluorouracil) and tamoxifen if ER+

Question 21

Toxicities include nephrotoxicity and ototoxicity, leading to a severe interaction with aminoglycosides

Answer 21

Cisplatin

Question 22

Regimen used for non-Hodgkin’s lymphoma

Answer 22

CHOP (cyclophosphamide, oncovin(vincristine), doxorubicin and prednisone), rituximab (rituxan)

Question 23

Nitrosoureas with high lipophilicity, used for brain tumors

Answer 23

Carmustine (BCNU) and lomustine (CCNU)

Question 24

Agent similar to cisplatin, less nephrotoxic, but greater myelosuppression

Answer 24

Carboplatin

Question 25

Some cell cycle specific anti-cancer drugs

Answer 25

Bleomycin, vinca alkaloids, antimetabolites (eg., 5-FU, 6-MP, methotrexate, etoposide)

Question 26

Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis

Answer 26

Bleomycin

Question 27

Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates

Answer 27

Allopurinol

Question 28

Interaction with this drug requires dose reduction of 6-MP

Answer 28

Allopurinol

Question 29

Some cell cycle non-specific drugs

Answer 29

Alkylating agents (eg., mechlorethamine, cyclophosphamide), antibiotics (doxorubicin, daunorubicin), cisplatin, nitrosourea

Question 30

MOA of cisplatin

Answer 30

Alkylating agent

Question 31

Analog of hypoxanthine, needs HGPRTase for activation

Answer 31

6-mercaptopurine (6-MP)

Question 32

Pyrimidine analog that causes “Thiamine-less death” given with leucovorin rescue

Answer 32

5-flouracil (5-FU)