Skeletal Muscle Relaxants

Question 1

Agent undergoing Hofmann elimination (breaking down spontaneously)

Answer 1

Atracurium

Question 2

During Phase I these agents worsen the paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine

Answer 2

Cholinesterase inhibitors

Question 3

These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)

Answer 3

Inhaled anesthetics, especially isoflurane, aminoglycosides, and antiarrhythmic

Question 4

Non-depolarizing antagonist has short duration

Answer 4

Mivacurium

Question 5

Structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation

Answer 5

Neuromuscular blocking drugs

Question 6

These prevent the action of Ach at the skeletal muscle endplate to produce a “surmountable blockade,” effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)

Answer 6

Nondepolarizing type antagonists

Question 7

Agent can blocking muscarinic receptors

Answer 7

Pancuronium

Question 8

One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis, causes muscle pain postoperatively and myoglobinuria may occur

Answer 8

Succinylcholine

Question 9

Agent with long duration of action and is sost likely to cause histamine release

Answer 9

Tubocurarine