Inhibitors or Corticosteroid Biosynth

Question 1

Diuretic used to antagonize aldosterone receptors

Answer 1

Spironolactone

Question 2

Antiprogestin used as potent antagonist of GC receptor

Answer 2

Mifepristone

Question 3

Used for Cushing’s syndrome (increased corticosteroid) and sometimes for adrenal function test

Answer 3

Metyrapone

Question 4

Antifungal agent used for inhibition of all gonadal and adrenal steroids

Answer 4

Ketoconazole

Question 5

Common SE of spironolactone

Answer 5

Gynecomastia and hyperkalemia

Question 6

Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis

Answer 6

Aminoglutethimide