Antiarrythmic Agents Flashcards
Adenosine’s MOA
Activates acetylcholine sensitive K+ channels in SA and AV node
DOC for paroxysmal supraventricular tachycardia (PSVT)
Adenosine
Anti-arrhythmic with <10 second duration of action
Adenosine
Class III antiarrhythmic that exhibits properties of all 4 classes
Amiodarone
Antiarrhythmic effective in most types of arrhythmia
Amiodarone
Class II antiarrhythmics are
B-blockers
Anti-arrhythmics that decrease mortality
B-blockers
MOA of class IV antiarrhythmics
Calcium channel blockers
Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents
Class IC (flecainide, propafenone, moricizine)
Drug used supraventricular arrhythmias
Digoxin
Used intravenously for acute arrhythmias during surgery
Esmolol
SE of phenytoin
Gingival hyperplasia
Major drug interaction with Quinidine
Increases concentration of Digoxin
DOC for management of acute Ventricular arrhythmias
Lidocaine
SE of procainamide
Lupus-like syndrome
Agent to treat torsades de pointes
Magnesium sulfate
DOC for digoxin induced arrhythmias
Phenytoin
MOA of class III antiarrhythmics
Potassium channel blockers
Specific pharmacokinetic characteristic of amiodarone
Prolonged half-life, up to six weeks
Side effect of sotalol
prolongs QT and PR interval
Limiting side effect of Quinidine
Prolongs QT interval
MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics
Sodium channel blockers
Antiarrhythmic that exhibits Class II and III properties
Sotalol
Other side effects of Quinidine
Thrombocytopenic purpura, and CINCHONISM
SE of Amiodarone
Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis
Life threatening cardiac event that prolong QT leads to
Torsades de pointes
