Opioid Analgesics and Antagonists

Question 1

Q

Answer 1

A

Question 2

Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons

Answer 2

Ascending pathways

Question 3

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

Answer 3

Buprenorphine

Question 4

Moderate opioid agonists

Answer 4

Codeine, hydrocodone, and oxycodone

Question 5

These agents are used as antitussive

Answer 5

Dextromethorphan, Codeine

Question 6

These agents are used as antidiarrheal

Answer 6

Diphenoxylate, Loperamide

Question 7

Opioid available trans-dermally

Answer 7

Fentanyl

Question 8

All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction

Answer 8

Meperidine

Question 9

Use of this opioid with MAOI can lead to hyperpyrexic coma, and with SSRI’s can lead to serotonin syndrome

Answer 9

Meperidine

Question 10

Opioid used in the management of withdrawal states

Answer 10

Methadone

Question 11

Tolerance to all effects of opioid agonists can develop except

Answer 11

Miosis, convulsions and constipation

Question 12

Opioid that can be given PO, by epidural, and IV, which helps to relieve the dyspnea of pulmonary edema

Answer 12

Morphine

Question 13

Opioids used in anesthesia

Answer 13

Morphine and fentanyl

Question 14

Strong opioid agonists

Answer 14

Morphine, methadone, meperidine, and fentanyl

Question 15

Opioid antagonist that is given IV and had short DOA

Answer 15

Naloxone

Question 16

Opioid antagonist that is given orally in alcohol dependency programs

Answer 16

Naltrexone

Question 17

SE of these drugs include dependence, withdrawal syndrome, sedation, euphoria, respiratory depression nausea and vomiting, constipation, biliary spasm, increased ureteral and bladder tone, and reduction in uterine tone

Answer 17

Opioid Analgesics

Question 18

Activation of these receptors open K+ ion channels to cause membrane hyperpolarization

Answer 18

Postsynaptic Mu receptors

Question 19

Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release and pain transmission

Answer 19

Presynaptic mu, delta, and kappa receptors

Question 20

Weak opioid agonist, poor analgesic, its overdose can cause severe toxicity including respiratory depression, circulatory collapse, pulmonary edema, and seizures

Answer 20

Propoxyphene