NSAIDS and DMARDS

Question 1

Q

Answer 1

A

Question 2

MOA of gold salts

Answer 2

Alter activity of macrophages and suppress phagocytic activity of PMNs

Question 3

Four main actions of NSAIDS

Answer 3

Anti-inflammatory, analgesia, antipyretic and antiplatelet activity

Question 4

Acetaminophen only has what activity?

Answer 4

Antipyretic and analgesic activity

Question 5

SE of penicillamine

Answer 5

Aplastic anemia and renal

Question 6

Difference between aspirin and other NSAIDS

Answer 6

Aspirin irreversibly inhibits cyclooxygenase

Question 7

Newer NSAIDs that selectively inhibit COX-2

Answer 7

Celecoxib

Question 8

SE of gold salts

Answer 8

Dermatitis of the mouth aplastic anemia and agranulocytosis

Question 9

COX 2 inhibitors may have reduced risk of

Answer 9

Gastric ulcers and GI Bleeding

Question 10

SE of acetaminophen

Answer 10

Hepatotoxicity

Question 11

Interferes with activity of T-lymphocytes

Answer 11

Hydroxychloroquine

Question 12

Anti-malarial drug used in rheumatoid arthritis (RA)

Answer 12

Hydroxychloroquine

Question 13

Agent used for closure of patent ductus arteriosus

Answer 13

Indomethacin

Question 14

Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)

Answer 14

Infliximab and etanercept

Question 15

MOA of NSAIDS

Answer 15

inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)

Question 16

MOA of Leflunomide (newer agent)

Answer 16

Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis

Question 17

NSAID available orally, IM, IV, nasally, and ophthalmically

Answer 17

Ketoralac

Question 18

NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity

Answer 18

Ketoralac

Question 19

Causes bone marrow suppression

Answer 19

Methotrexate

Question 20

Antidote for acetaminophen toxicity

Answer 20

N-acetylcysteine

Question 21

The reason why aspirin is contraindicated in children with viral infection

Answer 21

Potential for development of Reye’s syndrome

Question 22

COX 2 inhibitors should be used cautiously in pts with

Answer 22

Pre-existing cardiac or renal disease

Question 23

SE of hydroxychloroquine

Answer 23

Retinal destruction and dermatitis

Question 24

DMARDs are slow acting drugs for

Answer 24

Rheumatic disease

Question 25

Anti-rheumatic agent also used for ulcerative colitis

Answer 25

Sulfasalazine

Question 26

SE of salicylates

Answer 26

Tinnitus, GI bleeding