The Icteric Cat and Dog Flashcards

1
Q

where does heme come from?

A

red blood cells: hemoglobin, myoglobin, cytochrome

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2
Q

what percentage of septic cats have an increase in serum bilirubin?

A

63%

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3
Q

what infections can cause hemolytic anemia in cats?

A

mycocplasma
FeLV

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4
Q

what medications can cause hepatic icterus in cats?

A

oral diazepam
methimazole

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5
Q

what is the prevalence of lipid vacuoles in hepatic lipidosis?

A

> 50-60% of hepatocytes

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6
Q

what should you supplement in cats with idiopathic hepatic lipidosis?

A

glutathione
vitamin K
+/- vitamin B1
+/- carnitine

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7
Q

when is the prognosis of idiopathic feline hepatic lipidosis good?

A

if bilirubin decreases in first 5-7 days

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8
Q

what are the signs of acute neutrophilic cholangitis?

A

anorexia, lethargy, vomting
big three: fever, icterus, abdominal pain

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9
Q

what are the histologic patterns that cholantitis/cholecystitis can be?

A

acute neutrophilic cholangitis
chronic neutrophilic cholangitis
chronic lymphocytic cholangitis

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10
Q

what can lymphocytic cholangitis be hard to distinguish from?

A

small cell lymphoma

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11
Q

how can you treat lymphocytic cholangitis?

A

immunomodulation
hepatoprotectives
dietary: vitamin B12

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12
Q

what can cause post-hepatic icterus in a dog?

A

pancreatitis
gallbladder mucocele
cholelithiasis
cholecystitis

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13
Q

what is hyperbilirubinemia?

A

unusually large concentration of bilirubin in the blood
poor prognostic indicator in hepatobiliary and non-hepatobiliary disorders

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14
Q

how does sepsis cause cholestasis?

A

release of cytokines
down-regulation of hepatic transport proteins

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15
Q

is prehepatic icterus more common in dogs or cats?

A

dogs

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16
Q

what is abnormal in CBC, chem, abdominal effusion of hepatic lipidosis?

A

chem: increase liver enzymes, GGT slightly
abdominal effusion only if concurrent pancreatitis

17
Q

what is lymphoma like in the liver on ultrasound?

A

big, can be bright, dark, or nodular
increased lymph nodes
splenomegaly

18
Q

what does fine needle aspirate of the liver over diagnose?

A

vacuolar disease

19
Q

how can you treat small cell lymphoma in cats?

A

prednisolone
chlorambucil

20
Q

is an FNA diagnostic for lipidosis?

A

yes

21
Q

what is seen on laboratory tests for feline idiopathic hepatic lipidosis?

A

moderate to marked increase in ALP
mild to moderate increase in ALT
mild increase in GGT

22
Q

what should you avoid giving a cat with feline idiopathic hepatic lipidosis?

A

propofol anesthesia for extended periods
corticosteroids

23
Q

what should you feed cats with feline idiopathic hepatic lipidosis?

A

high calorie density
highest protein tolerated

24
Q

how is cholangitis/cholecystitis defined?

A

by histological pattern: acute neutrophilic cholangitis, chronic neutrophilic cholangitis, chronic lymphocytic cholangitis

25
Q

what is seen in laboratory testing with acute neutrophilic cholangitis?

A

mild to moderate neutrophilia +/- left shift
hyperbilirubinemia
increased ALT, AST, GGT, ALP

26
Q

what is best to perform aerobic and anaerobic cultures of for acute neutrophilic cholangitis?

A

gallbladder wall

27
Q

how can you treat acute neutrophilic cholangitis?

A

eliminate/treat predisposing factors
antibiotics for 6 weeks
hepatoprotectants and/or choleretics

28
Q

what are clinical signs with chronic neutrophilic cholangitis?

A

middle aged to older
chronic waxing/waning for years
episodic, vomiting, weight loss, hyporexia
icterus and hepatomegaly

29
Q

what is seen on laboratory testing with chronic neutrophilic cholangitis?

A

increased enzymes, ALP, GGT, ALT, AST
increased bilirubin

30
Q

what are signs like with lymphcytic cholangitis?

A

like chronic neutrophilic cholangitis, more chronic
may not be icteric until the end
older

31
Q

what is lymphoblastic lymphoma like?

A

involves other structures
middle aged to older
FeLV negative
heterogenous ultrasound

32
Q

what can cause post-hepatic icterus in a cat?

A

pancreatitis
neoplasia
cholelithiasis
cholecystitis
flukes