Feline Idiopathic Cystitis Flashcards
what cats are prone to feline idiopathic cystitis?
young cats
males and females
what are the clinical signs of feline idiopathic cystitis?
periuria
hematuria
dysuria
pollakiuria
urinary obstruction
what are the three layers of the urothelium?
basal cell layer
intermediate apical layer
superficial apical layer
what is responsible for maintaining the bladder permeability layer?
superficial urothelial cells
are antibiotics indicated for feline idiopathic cystitis?
rarely
how can you recognize a cat is obstructed?
large, painful bladder
elevated BUN, creatinine, phosphorous, sodium, potassium, chloride
urinalysis/culture
electrocardiogram
why is high output kidney injury worrisome?
hypokalemia
hyponatremia
balance ins and outs
what are the causes of FLUTD?
infections
uroliths or plugs
neoplasia
congenital or acquired abnormalities
trauma
neurogenic
idiopathic
how does nonobstructive idiopathic cystitis progress with age?
frequency and severity diminishes with age
what does disruption of the urothelial barrier lead to?
submucosal edema
hemorrhage
neovascularization
mastocytosis
mononuclear inflammatory cell infiltration
fibrosis
what happens in cats with feline idiopathic cystitis bladders?
have decreased GAGs
norepinephrine release causes NO: increased permeability of urothelium
what drugs can you give these cats?
buprenorphine
NSAIDs
flavoxate antispasmotic
what drugs can be given to these cats for managing chronic disease?
pheromones
tricyclic antidepressantss
GAGs: pentosan polysulfate, glucosamine
