Somatic nervous system skeletal and muscular contaction Flashcards

1
Q

what doses peripheral nervous system control?

A

Controls movement of skeletal muscles
- Voluntary movement

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2
Q

Ascending tracts

A

relay information from the spinal cord to the somatosensory cortex

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3
Q

Descending tracts

A

relay information from the motor cortex to the spinal cord

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4
Q

Sensory neurone

A
  • Sense touch, stretch, pain etc.
  • Relay information to spinal cord and brain
  • Enter spine at the dorsal horn, via dorsal root
  • Unipolar neurones – cell body is at dorsal root ganglion
  • Myelinated - speed action potential
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5
Q

Motor Neurones

A
  • Relay nerve impulses from the spine to trigger
  • Contraction of skeletal muscle
  • Exit spine via ventral root
  • ONE Alpha motor neurone
  • Multipolar and myelinated
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6
Q

Neuromuscular junction

A
  • Acetylcholine is the neurotransmitter at skeletal muscle NMJs
  • Shwann cell surrounds the presynaptic cleft ensure transmission
  • Binds to and activates Nicotinic Acetylcholine receptor which is Ionotropic ligand gated reponds quick
  • Post synaptic membrane termed Motor End Plate (MEP)
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7
Q

skeletal striated

A
  • Enables movement of limbs and other parts of the skeleton
  • Connected to bone
    • via tendons (origin)
    • via tendons (insertion)
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8
Q

Cardiac striated

A
  • The pump in the circulation (heart)
  • Functional syncytium
  • Intrinsic pacemaker activity
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9
Q

Smooth muscle

A
  • Functional syncytium
    Around many hollow internal organs
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10
Q

Structure of muscle fibre

A
  • Muscle belly
  • Fasciculus
  • Sarcolemma
  • Sarcoplasm & sarcoplasmic reticulum
  • Myofibrils
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11
Q

Protiens involved in contraction

A
  • Myosin
  • Actin
  • Troponin
  • Tropomyosin
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12
Q

I band

A
  • Contains only actin filiments
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13
Q

A I zone

A
  • Consists of both the A and the I band
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14
Q

H zone

A

Just contains the mysoin filiments

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15
Q

Z discs

A
  • At the terminal ends of the sarcomere
  • 1 sarcomere holds the actin filiments
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16
Q

Cross bridge cycling

A
  1. ATP binds to myosin
    Myosin releases actin
  2. Myosin hydrolyzes ATP and energy from ATP rotates the myosin head to the cocked position. Myosin binds weakly to actin.
  3. Power stroke begins when tropomyosin moves off the binding site. Ca2+ binds to troponin
  4. Myosin releases ADP at the end of the power stroke.
  5. ADP released - the myosin head tightly bound to actin, cycle is ready to begin once
    more as a new ATP binds to myosin.
17
Q

Excitation-Contraction- Coupling

A
  • Need ATP & Calcium
  • Triggers calcium release action potential
18
Q

Contration and sliding filiment theory

A
  • Sliding of myosin over actin filements and the H-zone disappers
19
Q

Events at NMJ

A
  • Action potential acytyl choline relase bind receptor
  • cause muscle end plate potential
    • muscle action potential
  • T-tubules deploarise open Ca2+ channel of sarcoplasmic reticulum
  • Sarcoplasmic Ca2+ increases
  • muscle fibre contracts
  • Ca2+ pumped back into SR
  • Muscle fibre relaxes
20
Q

acetylcholinergic movement in the presynaptic cleft

A
  • ACh formed in the synaptic terminal
  • Generated by ChAT
  • Packaged into vesicles
  • Calcium entry causes fusion of synaptic vesicles
  • Released into the synaptic cleft
  • some nicotinic ACh receptors
  • Broken down by Ach- esterase
  • Choline taken up reusing
21
Q

pharmacological
interference

A
  • Prevent packaging to synaptic vesicles and the transporting
22
Q

Botox and vescular release

A
  • Botulinum toxin from clostridium botulinum bacteria
    Inihibitor of vesicular fusion:
  • Alters proteins required for vesicular fusion with the presynaptic membrane
23
Q

Medical uses of botox

A

Severe muscular spasms - Blepharospasm
Children with cerebral palsy, motor neuron disease
Speech deficits following throat cancer