Pharmacology, Drugs and therapeutics Flashcards
1
Q
Pharmacodynamics
A
- Drugs action and mechanism in the body mechanism
2
Q
Pharmacokinetics
A
- What the body does to the drug via ADME
- Degredation of drug act as barrier
3
Q
What effect does a drug have?
A
-Elicits specific physiological response to the target organ
4
Q
Adrenaline effect on heart
A
- Binds with the Adrenergic receptor- beta (β-1)
- Increases heart rate & increasing the force of cardiac muscle contraction
5
Q
Adrenaline effect on lungs
A
- Binds to Adrenergic receptor- beta (β-2)
- Relaxes airways
- Dialates the smooth muscle
6
Q
Target binding site
A
- Provides the selectivity for the specific
binding of drugs/ligands (LOCK & KEY system)
7
Q
What is the purpose of a drug
A
- Act as an enzyme inhibitor
8
Q
Sildenafil
A
- Inhibition of the enzyme phosphodiesterase
- Decreases intracellular breakdoen of cGMP
- Treatment for erectile disfunction
9
Q
Neostigmine
A
- Inhibits the enzyme Acetylcholine esterase
- Decreases Neurotransmitter degradation
10
Q
Ibuprofen (reversible) & Aspirin (irreversible)
A
- Inhibits Cyclo-oxygenase enzyme
- Decreases messenger synthesis decreasing pain transmission
11
Q
Drug as enzyme substrate
A
- Dopamine precursor L-DOPA for Parkinson’s Disease
12
Q
Non-competitive binding
A
- Drug does not compete for the ligand active site
- The competitive inhibitor asprin inhibits arachidonic acid (precoursor) by binding it stimulates relase of prostioglandin
13
Q
Competitive binding
A
- Endogenous compound binds to the binding site
- Neostigmine with competitive to acetylcholine
14
Q
Drugs targeting transporters
A
- Transporter protiens noradrenaline released from the presynaptic can be taken back
- Could degrade if outside so take it back
- Any molecule in and out
15
Q
Cocaine
A
- Blocking of the transporter reducing the uptake of noradrenaline constant stimulation
