Pharmacology

Question 1

Salbutamol

Answer 1

• Anti asthma agonist Activates the (β-2) like adrenaline

Question 2

Propranolol

Answer 2

• Anti-hypertensive which decreases heart rate blocks the (β-1); decreases heart rate
• It is an Antagonist

Question 3

why does the dopomine molecule not bind to adenaline

Answer 3

Dopomine has a similar chemical structure as adrenaline but has its own dopamine receptors

Question 4

Receptor as molecule switch

Answer 4

• Free inactive
• bound inactive
• Bound active
• Causes response

Question 5

Affinity

Answer 5

How well the drug binds to its receptor

Question 6

Efficay

Answer 6

How well a drug/ligand activates the receptors, by confirmational changes of receptor

Question 7

Agonist

Answer 7

• Any drug that mimics a similar structure that can be bound giving simikar physological response

Question 8

Antagonist

Answer 8

Oppose the agonist function
makes site unavailable to bind for adrenaline

Question 9

Agonist effect on messengers

Answer 9

Agonist drugs have goodaffinity as it has good efficacy

Question 10

Antagonists effect on messenger hormone

Answer 10

Antogonist binds to receptor but cannot change the confirmation so no biological response

Question 11

Drug action measures equalibrium

Answer 11

Rate of forward is equal to backward free with unbound
Association = disassociation
K forward rate [D] [R] = K reverse rate [DR]

Question 12

X

Answer 12

Receptor drug complex

Question 13

Equation for drug occupancy

Answer 13

x = [D]/[D]+kD

Question 14

Equalibriam dissociation constant measure of drug affinity

Answer 14

kD is defined as concentration of drug required to occupy 50% of receptors (measure of drug affinity)