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PHSI 208 > Resp 7 > Flashcards

Resp 7 Flashcards

1
Q

Physical factors alternating hemoglobin’s affinity for O2

A
  • pH
  • PCO2
  • temperature
  • 2,3-DPG
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2
Q

Bohr effect

A

shift in hemoglobin saturation as a result in pH or CO2 change

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3
Q

Lower pH effect on Hb’s affinity for O2

A

decreased affinity; more O2 delivery (v.v)

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4
Q

Decreased PCO2 effect on Hb’s affinity for O2

A

decreased PCO2 means less O2 delivered (v.v)

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5
Q

Temperature on altering Hb’s affinity for O2

A

Increased temp. means more O2 delivery

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6
Q

Hypoxia increases ___________- production

A

2,3 DPG

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7
Q

Higher altitudes mean…

A

low atmospheric PO2 and increased 2,3 DPG production

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8
Q

Decreased 2,3DPG on altering Hb’s affinity for O2

A

increased O2 release (lower affinity)

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9
Q

fetal Hb composed of…

A

2 alpha, two gamma globulin subunits

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10
Q

maternal/adult Hb composed of…

A

two alpha, 2 beta subunits

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11
Q

Why is it important to remove CO2 from the body?

A

-elevated PCO2 causes acidosis and depresses CNS

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12
Q

7% of CO2 is…

A

carried by venous blood and dissolved in plasma

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13
Q

23% of CO2 is…

A

binds to Hb

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14
Q

70% of CO2 is…

A

converted to bicarbonate (HCO3-)

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15
Q

What is the purpose of converting CO2 to HCO3-?

A
  • provides additional means of CO2 transport from cells to lungs
  • HCO3- can act as buffer to stabilize body’s pH
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16
Q

carbonic anhydrase

A

converts CO2 to HCO3-

17
Q

To ensure equilibrium between conversion of CO2 to HCO3- and H+ is not reached, which two mechanisms exist?

A

-removal of HCO3- from RBC and Hb binding to excess H+ to prevent large changes in body’s pH and prevent acidosis

18
Q

carbaminohemoglobin

A

formed when CO2 binds to free Hb at amino group

19
Q

Formation of carbaminohemoglobin continues until..

A

PCO2 is equilibrated between cell, plasma, and RBC

20
Q

When plasma CO2 diffuses into alveoli…

A

everything basically reverses.. (RESP 7, slide 20)

PHSI 208 (64 decks)

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