Cardio 4 Flashcards
What two factors determine the amount of force generated by cardiac muscle?
- contractibility of the heart
- length of muscle fibres at beginning of contraction
inotropic agent
any chemical that affects contractibility
positive inotropic effect
chemicals increasing contractibility
negative inotropic effect
chemicals decreasing contractibility
Catecholamines
norepinephrine and epinephrine; positive inotropic effect
preload
degree of myocardial stretch prior to contraction
stretch
indicated by ventricular end-diastolic volume
frank starling law
stroke volume increases with increasing end-diastolic volume
skeletal muscle pump
Skeletal muscle activity compresses veins in the extremities pushing blood back to the heart
respiratory pump
during inspiration the chest expands and diaphragm moves down creating a subatmospheric pressure in the thoracic cavity, this draws blood into the vena cava that exist within this cavity
sympathetic constriction of veins
decreases their volume squeezing blood back towards that heart.
afterload
end load against which the heart contracts to eject blood
ejection fraction (EF) =
SV/EDV
progressive branching of vessels
Aorta>Arteries> arterioles> capillaries> venules > Veins>vena cava
arteries
all; mostly elastic tissue and smooth muscle