Pharm 7 Flashcards
Difference between COX 1 and COX 2
*COX 1 is found throughoutthe body and COX 2 is onlyin inflammatory tissue
Drug that selectively inhibits COX 2
Celecoxib, valdecoxib, and rofecoxib
Major SE of zileuton
Liver toxicity
Inhibitor of leukotrienes (LTD4) receptors and used in asthma
Zafirlukast and montelukast
Approved for use in severe pulmonary HTN
PGI2 (epoprostenol)
Irreversible, nonselective COX inhibitor
Aspirin
Class of drugs that reversibly inhibit COX
NSAIDS
Primary endogenous substrate for Nitric Oxidase Synthase
Arginine
Long acting beta 2 agonist used in asthma
Salmeterol
Enzyme which theophylline inhibits
Phosphodiesterase
Methylxanthine derivative used as a remedy for intermittent claudication
Pentoxifylline
Antidote for severe CV toxicity of theophylline
Beta blockers
MOA of corticosteroids
inhibit phospholipase A2
MOA of penicillin
Block cell wall synthesis by inhibiting peptidoglycan cross-linkage
Type of resistance found with vancomycin
Point mutation
Two toxicities of aminoglycosides
nephro and ototoxicity
DOC for Legionnaires’ disease
Levofloxacin or azithromycin
Penicillins active against penicillinase secreting bacteria
Methicillin, nafcillin, and dicloxacillin
Class of antibiotics that have 10% cross sensitivity with penicillins
Cephalosporins
Aztreonam has NO cross sensitivity
- GNR only
PCN active against pseudomonas
Carbenicillin, piperacillin and ticarcillin
“TCP”
Antibiotic causing red-man syndrome, and prevention
Vancomycin, infusion at a slow rate and antihistamines
Drug causes teeth discoloration
Tetracycline
MOA of tetracycline
Decreases protein synthesis by inhibiting 30S ribosome
Drug that causes gray baby syndrome and aplastic anemia
Chloramphenicol
Drug notorious for causing pseudomembranous colitis
Clindamycin
Treatment of resistant pseudomembranous colitis
ORAL vancomycin
Reason fluoroquinolones are contraindicated in children and pregnancy
Cartilage damage
Metronidazole SE if given with alcohol
Disulfiram-like reaction
MOA of nystatin
Bind ergosterol in fungal cell membrane
Inducers of CYP450
Rifampin Griseofulvin Barbiturates Carbamazepine Phenytoin
