Pharm 1

Question 2

Relates the amount of drug in the body to the plasma concentration

Answer 2

Volume of distribution (VD)

Question 3

Plasma concentration of a drug at a given time

Answer 3

Cp

Question 4

The ratio of the rate of elimination of a drug to its plasma concentration

Answer 4

Clearance (CL)

Question 5

The elimination of drug that occurs before it reaches the systemic circulation

Answer 5

First pass effect

Question 6

The fraction of administered dose of a drug that reaches systemic circulation

Answer 6

Bioavailability (F)

Question 7

When the rate of drug input equals the rate of drug elimination

Answer 7

Steady state

Question 8

Different steps of Phase I

Answer 8

Hydrolysis, oxidation, reduction

That 1 is a HOR

Question 9

Products of Phase II conjugation

Answer 9

Glucuronate, acetic acid, and glutathione sulfate

GAS - glucuronidation, acetylation, sulfation

Question 10

Constant percentage of substrate metabolized per unit time

Answer 10

First order kinetics

Question 11

Drug elimination with a constant amount metabolized regardless of drug concentration

Answer 11

Zero order kinetics

Question 12

Target plasma concentration x (volume of distribution / bioavailability)

Answer 12

Loading dose (Cp*(Vd/F))

Question 13

Concentration in the plasma x (clearance / bioavailability)

Answer 13

Maintenance dose (Cp*(CL/F))

Question 14

Strength of interaction between drug and its receptor

Answer 14

Affinity

Question 15

Selectivity of a drug for its receptor

Answer 15

Specificity

Question 16

Amount of drug necessary to elicit a biologic effect

Answer 16

Potency

Question 17

Ability of a drug to produce 100% of the maximum response regardless of the potency

Answer 17

Full agonist

Question 18

Ability to produce less than 100% of the response

Answer 18

Partial agonist

Question 19

Ability to bind reversibly to the same site as the drug and without activating the effector system

Answer 19

Competitive antagonist

Question 20

Ability to bind to either the same or different site as the drug

Answer 20

Noncompetitive antagonist

Question 21

MOA utilizes ligand gated ion channels

Answer 21

Benzodiazepines and calcium channel blockers

Question 22

Median effective dose required for an effect in 50% of the population

Answer 22

ED50

Question 23

Median toxic dose required for a toxic effect in 50% of the population

Answer 23

TD50

Question 24

Window between therapeutic effect and toxic effect

Answer 24

Therapeutic index

Question 25

Drug with a high margin of safety

Answer 25

High therapeutic index