HY Pharm 2

Question 2

Common SE of spironolactone

Answer 2

**Gynecomastia and hyperkalemia

Question 3

Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study)

Answer 3

*Raloxifene

Question 4

Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy

Answer 4

*Diethylstilbestrol (DES)

Question 5

Converted to more active form DHT by 5 alpha-reductase

Answer 5

*Testosterone

Question 6

Product of proinsulin cleavage used to assess insulin production

Answer 6

*C-peptide

Question 7

Long acting insulin

Answer 7

*Ultralente (humulin U)

Question 8

Amino acid derivative for treatment of Type II diabetes

Answer 8

*Nateglinide

Question 9

Increase bone density, also being tested for breast CA tx.

Answer 9

*Raloxifene (SERM-selective estrogen receptor modulator)

Question 10

Used intranasally and decreases bone resorption

Answer 10

*Calcitonin (salmon prep)

Question 11

Drug that causes contraction of the uterus

Answer 11

*Oxytocin

Question 12

Distribution of histamine receptors H1, H2, and H3

Answer 12

*Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

Question 13

Prototype antagonist of H1 and H2 receptors

Answer 13

*Diphenhydramine

Question 14

1st generation antihistamine that is highly sedating

Answer 14

**Diphendydramine

Question 15

2nd generation antihistamines

Answer 15

*Fexofenadine, loratadine, and cetirizine

Question 16

H2 blocker that causes the most interactions with other drugs

Answer 16

*Cimetidine

Question 17

5HT-1D/1B agonist used for migraine headaches

Answer 17

**Sumatriptan, naratriptan, and rizatriptan

Question 18

Agents for reduction of postpartum bleeding

Answer 18

**Oxytocin and ergonovine

Question 19

Agents used in treatment of carcinoid tumor

Answer 19

**Cyproheptadine

Question 20

5HT-3 antagonist used in chemotherapeutic induced emesis

Answer 20

Aprepitant, Ondansetron, granisetron, dolasetron and palonosetron

Question 21

Ergot alkaloid used as an illicit drug

Answer 21

*LSD

Question 22

Dopamine agonist used in hyperprolactinemia

Answer 22

*Bromocriptine

Question 23

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

Answer 23

*Bradykinin

Question 24

Drug causing depletion of substance P (vasodilator)

Answer 24

*Capsaicin

Question 25

Prostaglandins that cause abortions

Answer 25

*Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

Question 26

Inhibitor of lipoxygenase

Answer 26

*Zileuton