HY Pharm 4

Question 1

The most common neurologic abnormality in chronic alcoholics

Answer 1

*Peripheral neuropathy (also HTN, anemia, and MI)

Question 2

Drugs of choice for generalized tonic-clonic and partial seizures

Answer 2

*Valproic acid, Phenytoin and Carbamazepine

Question 3

Drugs of choice for absence seizures

Answer 3

*Ethosuximide and valproic acid

Question 4

Drug of choice for myoclonic seizures

Answer 4

*Valproic acid

Question 5

Anti-seizure drugs used also for pain of neuropathic orgin

Answer 5

*Gabapentin

Question 6

SE of phenytoin

Answer 6

Diplopia, ataxia, nystagmus, gingival hyperplasia (DANG)

Question 7

DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics

Answer 7

*Dantrolene

Question 8

Benzodiazepine receptor antagonist, it accelerates recovery from benzodiazepine overdose

Answer 8

*Flumazenil

Question 9

Opioid associated with awareness during surgery and post-operative recall, but still used for high-risk cardiovascular surgeries

Answer 9

*Fentanyl

Question 10

DOC for malignant hyperthermia by acting on the sacroplasmic reticulum of skeletal muscle

Answer 10

*Dantrolene

Question 11

Causes of drug induced Parkinsonism

Answer 11

Antipsychotics
Reserpine at high doses
MPTP (by-product of illicit meperidine analog)

irreversible

Question 12

Side effects occuring in antipsychotics that block dopamine

Answer 12

*EPS, hyperprolactinemia, amennorrhea, galactorrhea, neuroleptic malignant syndrome

Question 13

Atypical antipsychotic causing high prolactin levels

Answer 13

*Risperidone

Question 14

Drug used in neuroleptic malignant syndrome

Answer 14

*Dantrolene

Question 15

Antipsychotics having the strongest autonomic effects

Answer 15

*Chlorpromazine or Thioridazine

Question 16

Agent with greater affinity to 5HT2A receptor; reserved for refractory schizophrenia, and can cause weight gain and agranulocytosis

Answer 16

*Clozapine (H1 blocker)

Question 17

Anti-psychotics shown not to cause tardive dyskinesia

Answer 17

*Clozapine and quetiapine

Question 18

Major route of elimination for Lithium

Answer 18

*Kidneys

Question 19

DOC for bipolar affective disorder

Answer 19

*Lithium

Question 20

SE of lithium

Answer 20

*Tremor/excitation, ataxia, aphasia, HYPOTHYROIDISM, and reversible diabetes insipidus

Question 21

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Answer 21

*Protease inhibitors

Question 22

DOC for N. gonorrhea

Answer 22

*Ceftriaxone

Question 23

DOC for herpes and its MOA

Answer 23

*Acyclovir; activates thymidine kinase

Question 24

Anti-microbials that cause hemolysis in G6PD-deficient patients

Answer 24

*Sulfonamides

Question 25

SE of Protease inhibitors

Answer 25

Lipodystrophy, kidneys stones, inhibits P450 (don’t use rifampin)