Pharm 13

Question 2

MAOI should not be administered with SSRI’s or potent TCA’s due to development of this condition

Answer 2

Serotonin syndrome

Tach, sweating, dilated pupils, myoclonus, hyperreflexia, hyperthermia

Question 3

Sedation is a common side effect of these drugs.
Lower seizure threshold.
Uses = BAD, acute panic attacks, phobias, enuresis, and chronic pain
Overdose = lethal

Answer 3

Tricyclic antidepressants (TCA)

Question 4

Three C’s associated with TCA toxicity

Answer 4

Coma, Convulsions, Cardiac problems (arrhythmias and wide QRS)

Question 5

Agents having higher sedation and antimuscarinic effects than other TCA’s

Answer 5

Tertiary amines

Question 6

A hypnotic & TCA used in chronic pain, that has marked antimuscarinic effects

Answer 6

Amitriptyline

Question 7

TCA with greatest sedation of this group, and marked antimuscarinic effects, used for sleep

Answer 7

Doxepin

Question 8

TCA used in OCD.

Most significant of TCA’s for risk of seizure, weight gain, and neuropsychiatric signs and symptoms

Answer 8

Clomipramine

Question 9

Secondary amines that have less sedation and more excitation effect

Answer 9

Nortriptyline, Desipramine

Question 10

Antidepressant associated with neuroleptic malignant syndrome

Answer 10

Amoxapine

Question 11

Antidepressant associated with seizures and cardiotoxicity

Answer 11

Maprotiline

Question 12

Antidepressant having stimulant effects similar to SSRI’s and can increase blood pressure

Answer 12

Venlafaxine

Question 13

Antidepressant inhibiting norepinephrine, serotonin, and dopamine reuptake

Answer 13

Venlafaxine

Question 14

Antidepressant used for sleep that causes priapism

Answer 14

Trazodone

Question 15

Antidepressant which is an inhibitor of CYP450 and may be associated with hepatic failure

Answer 15

Nefazodone

Question 16

Antidepressant with MOA as alpha 2 antagonist, has effects on both 5-HT and NE, blocks histamine receptors, and is sedating

Answer 16

Mirtazapine

Question 17

SE of mirtazapine

Answer 17

Liver toxicity, increased serum cholesterol

Question 18

Except for these agents all SSRI have significant inhibition of CYP450 enzymes

Answer 18

Citalopram and its metabolite escitalopram

Question 19

SSRI with long T1/2 and can be administered once weekly for maintenance, not acute tx

Answer 19

Fluoxetine

Question 20

SSRI indicated for premenstrual dysphoric disorder

Answer 20

Fluoxetine (Sarafem)

Question 21

Some of SSRIs’ therapeutic effects beside depression

Answer 21

Panic attacks, social phobias, bulimia nervosa, and PMDD premenstrual dysphoric disorder), OCD

Question 22

SSRI less likely to cause a withdrawal syndrome

Answer 22

Fluoxetine

Question 23

Activation of these receptors open K+ ion channels to cause membrane hyperpolarization

Answer 23

Postsynaptic Mu receptors

Question 24

All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction

Answer 24

Meperidine

Question 25

SE of these drugs include dependence, withdrawal syndrome, sedation, euphoria, respiratory depression nausea and vomiting, constipation, biliary spasm, increased ureteral and bladder tone, and reduction in uterine tone

Answer 25

Opioid Analgesics

Question 26

Strong opioid agonists

Answer 26

Morphine, methadone, meperidine, and fentanyl

Question 27

Opioids used in anesthesia

Answer 27

Morphine and fentanyl

Question 28

Use of this opioid + MAOI –> hyperpyrexic coma

Use of this opioid + SSRIs –> serotonin syndrome

Answer 28

Meperidine

Question 29

Weak opioid agonist, poor analgesic

Overdose –> severe toxicity including respiratory depression, circulatory collapse, pulmonary edema, and seizures

Answer 29

Propoxyphene