Pharm 4

Question 2

GnRH agonist used for infertility - pulsatile usage

Different types of CA - steady usage

Answer 2

Leuprolide

Question 3

GnRH antagonist with more immediate effects, used for infertility

Answer 3

Ganirelix

Question 4

T3 compound less widely used

Answer 4

Cytomel

Question 5

Anti-thyroid drugs

Answer 5

Thioamides, iodides, radioactive iodine, and ipodate

Question 6

Thioamide agents used in hyperthyroidism

Answer 6

Methimazole and propylthiouracil (PTU)

Question 7

Can be effective for short term therapy of thyroid storm, but after several weeks of therapy causes an exacerbation of hyperthyroidism

Answer 7

Iodide salts

Question 8

Permanently cures thyrotoxicosis, patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy

Answer 8

Radioactive iodine

Question 9

Radio contrast media that inhibits the conversion of T4 to T3

Answer 9

Ipodate

Question 10

Block cardiac adverse effects of thyrotoxicosis such as tachycardia, inhibits the conversion of T4 to T3

Answer 10

Beta-blockers such as propranolol

Question 11

3 zones of adrenal cortex and their products

Answer 11

“GFR”
Glomerulosa (mineralocorticoids)
Fasciculata (glucocorticoid=GC)
Reticularis (adrenal androgens)

Question 12

Pneumonic for 3 zones of adrenal cortex

Answer 12

GFR

Question 13

Used for Addison’s disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)

Answer 13

Glucocorticoids

Question 14

Short acting GC’s

Answer 14

Cortisone and hydrocortisone (equivalent to cortisol)

Question 15

Intermediate acting GC’s

Answer 15

Prednisone, methylprednisolone, prednisolone, and triamcinolone

Question 16

Long acting GC’s

Answer 16

Betamethasone, dexamethasone, and paramethasone

Question 17

Mineralocorticoids

Answer 17

Fludrocortisone and deoxycorticosterone

Question 18

Period of time of therapy after which GC therapy will need to be tapered

Answer 18

5-7 days

Question 19

Used for Cushing’s syndrome (increased corticosteroid) and sometimes for adrenal function test

Answer 19

Metyrapone

Question 20

Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis

Answer 20

Aminoglutethimide

Question 21

Antifungal agent used for inhibition of all gonadal and adrenal steroids

Answer 21

Ketoconazole

Question 22

Antiprogestin used as potent antagonist of GC receptor

Answer 22

Mifepristone

Question 23

Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss

Answer 23

Estrogen

Question 24

Antiestrogen drugs used for fertility and breast cancer respectively

Answer 24

Clomiphene and tamoxifen

Question 25

Common SE of tamoxifen and raloxifene

Answer 25

Hot flashes

Question 26

Estrogen mostly used in oral contraceptives (OC)

Answer 26

Ethinyl estradiol and mestranol

Question 27

Anti-progesterone used as abortifacient

Answer 27

Mifepristone (RU-486)

Question 28

Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)

Answer 28

Combination oral contraceptives (OC)

Question 29

Oral contraceptive available in a transdermal patch

Answer 29

Ortho-Evra

Question 30

5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness

Answer 30

Finasteride (Proscar and Propecia respectively)

Question 31

Anabolic steroid that has potential for abuse

Answer 31

Nandrolone and stanozolol