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Immuno/Micro Flashcards

1
Q

Anti-nuclear Abs

A

SLE, nonspecific

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2
Q

Anti-dsDNA

A

SLE

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3
Q

Anti-Smith

A

SLE

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4
Q

Antihistone

A

Drug-induced lupus

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5
Q

Anti-IgG (Rheumatoid factor)

A

RA

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6
Q

Anticentrosome

A

Scleroderma (CREST)

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7
Q

Anti-Scl70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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8
Q

Anti-mitochondrial

A

Primary biliary cirrhosis

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9
Q

Antigliadin

A

Celiac

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10
Q

Antiendomysial

A

Celiac

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11
Q

Anti-basement membrane

A

Goodpasture’s

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12
Q

Anti-desmoglein

A

Pemphigus vulgaris

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13
Q

Antimicrosomal

A

Hashimoto’s

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14
Q

Antithyroglobulin

A

Hashimoto’s

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15
Q

Anti-Jo-1

A

Polymyostitis, dermatomyostitis

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16
Q

Anti-SS-A (anti-Ro)

A

Sjogren’s

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17
Q

Anti-SS-B (Anti-La)

A

Sjogrens’s

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18
Q

Anti-U1 RNP

A

Mixed CT disease

19
Q

Anti-smooth muscle

A

Autoimmune hepatitis

20
Q

Anti-glutamate decarboxylase

21
Q

c-ANCA

A

Wegener’s

22
Q

p-ANCA

A

Churg-Strauss (asthma)
Polyangitis
Ulcerative colitis

23
Q

Recurrent infections with Staph, Kleb, serratia, cacdida, PA and aspergillus.

A

CGD

NADPH oxidase deficiency
Catalase + bacteria infections
NBT test yellow (-)

24
Q

IgA in small vessel walls

A

Henoch-Schonlein purpura

25
Q

Recurrent infections, omphalitis, gum inflammation, CD18-

A

Leukocyte adhesion deficiency

No integrins = no leukocyte migration
Failure to form pus

26
Q

Partial albinism, recurrent bacterial infections, CD56-

A

Chediak-Higashi

27
Q

Recurrent infections with Candida, no anti-CD3, no concanavalin or phytohemagglutinin

A

DiGeorge syndrome

No T-cells
Failure of 3rd and 4th pouches
Facial abnormalities, cardiac
No live vaccines

28
Q

MHC class I deficiency

A

Failure of TAP1
NO CD8
CD4 normal
Normal DTH, Ab

29
Q

MHC class II deficiency

A

SCID

No CD4

30
Q

Recurrent meningitis or gonoccoal infections

A

C5-9 (MAC) deficiency

Tx = ceftriaxone

31
Q

C1-inhibitor deficiency

A

Hereditary angioedema

32
Q

C1-4

A

Viral Neutralization

33
Q

C3b

A

Opsonization (also IgG)

34
Q

C3a, C5a

A

Anaphylatoxins

Binds mast cells directly

35
Q

C5a

A

Neutrophil Chemotaxis

36
Q

C5b-9

37
Q

Pneumonia for 6mo. Recurrent infections w/ encapsulated bacteria and viral infections, CD19-

A

Bruton’s
Tyrosine Kinase

No B-cells
CD19-

38
Q

Recurrent bacterial infections and severe diarrhea, high serum IgM

A

Hyper IgM

Deficiency of CD40L

39
Q

Most common immune deficiency

A

IgA deficiency

Repeated sinopulmonary & GI infections

40
Q

Deficiency of gamma chain IL-2

A

X-linked SCID

41
Q

Adenosine deaminase deficiency

42
Q

Recombinase deficiency

A

SCID
Rag1 or 2 nonsense mutations
No B or T cells

43
Q

Thrombocytopenic purpura, eczema, low Ig

A

Wiskott-Aldrich syndrome

Classic triad

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