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Step 1 > Pharm 2 > Flashcards

Pharm 2 Flashcards

2
Q

Drug with a narrow margin of safety

A

Low therapeutic index

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3
Q

Antidote used for lead poisoning

A

Dimercaprol, EDTA

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4
Q

Antidote used for cyanide poisoning

A

Nitrites

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5
Q

Antidote used for anticholinergic poisoning

A

Physostigmine

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6
Q

Antidote used for iron salt toxicity

A

Deferoxamine

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7
Q

Antidote for severe lead poisoning

A

Dimercaprol + CaEDTA (edetate calcium disodium)

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8
Q

Antidote for arsenic, mercury, and gold poisoning

A

Dimercaprol

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9
Q

Antidote used in Wilson’s disease (copper poisoning)

A

Penicillamine

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10
Q

Antidote used for methanol and ethylene glycol

A

Ethanol

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11
Q

Antidote used for tricyclic antidepressants (TCA)

A

Sodium bicarbonate

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12
Q

Antidote used for carbon monoxide poisoning

A

100% O2 and hyperbaric O2

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13
Q

Antidote used for digitalis toxicity

A

Digibind (also need to d/c digoxin, normalize K+, and lidocaine if pt. Is arrhythmic)

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14
Q

Antidote used for beta agonist toxicity (eg. Metaproterenol)

A

Esmolol

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15
Q

Antidote for methotrexate toxicity

A

Leucovorin

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16
Q

Antidote for beta-blockers and hypoglycemia

A

Glucagon

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17
Q

Antidote useful for some drug induced Torsade de pointes

A

Magnesium sulfate

18
Q

Antidote for hyperkalemia

A

sodium polystyrene sulfonate (Kayexalate)

19
Q

Antidote for salicylate intoxication

A

Alkalinize urine, dialysis

20
Q

Constant proportion of cell population killed rather than a constant number

A

Log-kill hypothesis

21
Q

Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously

A

Pulse therapy

22
Q

Toxic effect of anticancer drug can be lessened by rescue agents

A

Rescue therapy

23
Q

Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates

A

Allopurinol

24
Q

Pyrimidine analog that causes “Thiamine-less death” given with leucovorin rescue

A

5-flouracil (5-FU)

25
Q

Drug used in cancer therapy causes Cushing-like symptoms

A

Prednisone

26
Q

Side effect of Mitomycin

A

SEVERE myelosuppression

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