Pharm 3

Question 2

MOA of cisplatin

Answer 2

Alkylating agent

Question 3

Common toxicities of cisplatin

Answer 3

Nephro and ototoxicity

Question 4

Analog of hypoxanthine, needs HGPRTase for activation

Answer 4

6-mercaptopurine (6-MP)

Question 5

Bleomycin + vinblastine + etoposide + cisplatin produce almost a 100% response when all agents are used for this neoplasm

Answer 5

Testicular cancer

Question 6

MOPP regimen used in Hodgkin’s disease (HD)

Answer 6

Mechlorethamine + oncovorin (vincristine) + procarbazine, and prednisone

Question 7

ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP

Answer 7

Adriamycin (doxorubicin) + bleomycin, vinblastine + dacarbazine

Question 8

Regimen used for non-Hodgkin’s lymphoma

Answer 8

COP (cyclophosphamide, oncovorin (vincristine), and prednisone)

Question 9

Regimen used for breast cancer

Answer 9

CMF (cyclophosphamide, methotrexate, and fluorouracil) and tamoxifen if Estrogen-Receptor +

Question 10

Alkylating agent, vesicant that causes tissue damage with extravasation

Answer 10

Mechlorethamine

Question 11

Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis

Answer 11

Cyclophosphamide

Question 12

Prevention of cyclophosphamide induced hemorrhagic cystitis

Answer 12

Hydration and mercaptoethanesulfonate (MESNA)

Question 13

Microtubule inhibitor that causes peripheral neuropathy, foot drop (eg. ataxia), and “pins and needles” sensation

Answer 13

Vincristine

Question 14

Toxicities include nephrotoxicity and ototoxicity, leading to a severe interaction with aminoglycosides

Answer 14

Cisplatin

Question 15

Agent similar to cisplatin, less nephrotoxic, but greater myelosuppression

Answer 15

Carboplatin

Question 16

Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)

Answer 16

L-asparaginase

Question 17

Used for hairy cell leukemia; it stimulates NK cells

Answer 17

Interferon alpha

Question 18

Anti-androgen used for prostate cancer

Answer 18

Flutamide (Eulexin)

Question 19

Newer estrogen receptor antagonist used in advanced breast cancer

Answer 19

Toremifene (Fareston)

Question 20

Some cell cycle specific anti-cancer drugs

Answer 20

Bleomycin, antimetabolites (5-FU, 6-MP, MTX, etoposide), vinca alkaloids

“BAV”

Question 21

Some cell cycle non-specific drugs

Answer 21

Alkylating agents (mechlorethamine, cyclophosphamide), nitrosourea, cisplatin, antibiotics (doxorubicin, daunorubicin)

ANCA

Question 22

Nitrosoureas with high lipophilicity, used for brain tumors

Answer 22

Carmustine (BCNU) and lomustine (CCNU)

Question 23

Alkylating agent that produces disulfiram-like reaction with ethanol

Answer 23

Procarbazine

Question 24

Somatostatin (SRIF) analog used for acromegaly, carcinoid, glucagonoma and other GH producing pituitary tumors

Answer 24

Octreotide

Question 25

Somatotropin (GH) analog used in GH deficiency (dwarfism)

Answer 25

Somatrem

Question 26

GHRH analog used as diagnostic agent

Answer 26

Sermorelin