Pharm 3 Flashcards
MOA of cisplatin
Alkylating agent
Common toxicities of cisplatin
Nephro and ototoxicity
Analog of hypoxanthine, needs HGPRTase for activation
6-mercaptopurine (6-MP)
Bleomycin + vinblastine + etoposide + cisplatin produce almost a 100% response when all agents are used for this neoplasm
Testicular cancer
MOPP regimen used in Hodgkin’s disease (HD)
Mechlorethamine + oncovorin (vincristine) + procarbazine, and prednisone
ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP
Adriamycin (doxorubicin) + bleomycin, vinblastine + dacarbazine
Regimen used for non-Hodgkin’s lymphoma
COP (cyclophosphamide, oncovorin (vincristine), and prednisone)
Regimen used for breast cancer
CMF (cyclophosphamide, methotrexate, and fluorouracil) and tamoxifen if Estrogen-Receptor +
Alkylating agent, vesicant that causes tissue damage with extravasation
Mechlorethamine
Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis
Cyclophosphamide
Prevention of cyclophosphamide induced hemorrhagic cystitis
Hydration and mercaptoethanesulfonate (MESNA)
Microtubule inhibitor that causes peripheral neuropathy, foot drop (eg. ataxia), and “pins and needles” sensation
Vincristine
Toxicities include nephrotoxicity and ototoxicity, leading to a severe interaction with aminoglycosides
Cisplatin
Agent similar to cisplatin, less nephrotoxic, but greater myelosuppression
Carboplatin
Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)
L-asparaginase
Used for hairy cell leukemia; it stimulates NK cells
Interferon alpha
Anti-androgen used for prostate cancer
Flutamide (Eulexin)
Newer estrogen receptor antagonist used in advanced breast cancer
Toremifene (Fareston)
Some cell cycle specific anti-cancer drugs
Bleomycin, antimetabolites (5-FU, 6-MP, MTX, etoposide), vinca alkaloids
“BAV”
Some cell cycle non-specific drugs
Alkylating agents (mechlorethamine, cyclophosphamide), nitrosourea, cisplatin, antibiotics (doxorubicin, daunorubicin)
ANCA
Nitrosoureas with high lipophilicity, used for brain tumors
Carmustine (BCNU) and lomustine (CCNU)
Alkylating agent that produces disulfiram-like reaction with ethanol
Procarbazine
Somatostatin (SRIF) analog used for acromegaly, carcinoid, glucagonoma and other GH producing pituitary tumors
Octreotide
Somatotropin (GH) analog used in GH deficiency (dwarfism)
Somatrem
GHRH analog used as diagnostic agent
Sermorelin
