Neurotransmitter Explanation of Schizophrenia

Question 1

What do you use to prevent dopamine stimulating

Answer 1

Use dopamine antagonist

Question 2

Enzyme and how it works with dopamine to make someone schizophrenic

Answer 2

Low levels of beta hydroxylase leads to excess dopamine in synapse

Question 3

What does beta hydroxylase do

Answer 3

Breaks up dopamine into dopamine metabolites
Reduces amount of dopamine made

Question 4

Seeman (2013)

Answer 4

People diagnosed with schizophrenia have 6% more D2 high receptors
Profileration of D2 receptors means more dopamine can be binded with to produce more signals

Question 5

Snyder (1985)

Answer 5

Some antipsychotic medications are highly affective despite only blocking narrow range of receptor types

Question 6

Dopamine agonist name

Answer 6

Apomorphine

Question 7

What does Apomorphine do

Answer 7

Stimulates dopamine receptors but doesnt make people psychotic
So, schizophrenia cannot be solely caused by dopamine excess

Question 8

Drug that works well to stopping Dopamine being in excess and prevents schizophrenia

Answer 8

Clozapine

Question 9

How does clozapine work

Answer 9

Binds to D1 and D4 receptors
Weakly binds to D2
Also binds to serotonin

Question 10

Two pathways responsible for dopamine levels affecting schizophrenia

Answer 10

Mesolimbic vs Mesocortical

Question 11

Relation between Mesolimbic and Mesocortical pathways

Answer 11

Mesocortical = too little dopamine, get negative symptoms
Mesolimbic = too much dopamine, get positive symptoms
(When one gets too much dopamine the other lowers)