Haem- paraproteinaemias Flashcards
1
Q
what is multiple myeloma
A
plasma cell dyscrasia characterised by abnormal clonal proliferation of post-germinal b cells (plasma cells)
1
Q
median age of multiple myeloma
A
elderly- 65 years
2
Q
risk factors of multiple myeloma
A
male sex
black African ethnicity
family history
obesity
3
Q
clinical features of multiple myeloma
A
bone pain- most commonly backache
weakness
fatigue
anaemia
weight loss
recurrent infections
Rarely, symptoms/signs of hyperviscosity and bleeding due to thrombocytopenia (easy bruising/bleeding etc.)
4
Q
signs of multiple myeloma
A
hypercalcaemia
anaemia
renal failure
lytic bone lesions
