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My Flashcards Year 2 > Haem- drugs > Flashcards

Haem- drugs Flashcards

1
Q

mechanism of action of aspirin

A

inhibits cyclo-oxygenase which is necessary to produce thromboxane A2

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2
Q

adverse effects of aspirin

A

bleeding
blocks production of prostaglandins- GI ulceration, bronchospasm

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3
Q

heparin

A

anti-coagulant

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4
Q

anti-coagulants aka

A

blood thinners- prevent blood clots forming

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5
Q

aspirin

A

anti-platelet agent

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6
Q

anti-platelet agents

A

prevent platelets clumping together- prevents blood clots forming

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7
Q

moa of heparin

A

potentiates antithrombin (immediate effect)

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8
Q

antithrombin

A

a protein in the blood that plays a crucial role in regulating blood clotting

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9
Q

warfarin

A

anti-coagulant

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10
Q

moa of warfarin

A

inhibit vitamin K

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11
Q

main indications for anticoagulants

A

venous thrombosis
atrial fibrillation

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12
Q

what do anticoagulant drugs target

A

the formation of the fibrin clot

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13
Q

monitoring unfractioned heparin

A

Activated partial thromboplastin time (APPT)

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14
Q

monitoring LMWH

A

Anti-Xa assay but usually no monitoring of LMWH is required as more predictable response

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15
Q

complications of heparin

A

bleeding
heparin induced thrombocytopenia
osteoporosis

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16
Q

drug used to reverse effects of heparin in severe bleeding

A

protamine sulphate

17
Q

coumarin anticoagulants moa

A

inhibit vitamin K

18
Q

factors that require vitamin K

A

Factors II (prothrombin), VII, IX & X
Protein C and protein S

19
Q

contraindication and cautions of warfarin

A

has a narrow therapeutic window - need to monitor therapy using INR

20
Q

recommended time of day to take warfarin

A

same time each day 6pm recommended

21
Q

major adverse effect of warfarin

A

haemorrhage

22
Q

MOA of clopidogrel and prsaugrel

A

ADP receptor antagonists

23
Q

moa of Dipyridamole

A

Phosphodiesterase inhibitor - increases production of cAMP which inhibits platelet aggregation

24
Q

moa of GP IIb/IIIa inhibitors

A

Inhibit aggregation

25
Q

activated partial thromboplastin time (APTT)

A

test measures how long it takes blood to clot

My Flashcards Year 2 (35 decks)

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