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My Flashcards Year 2 > MSK- drugs > Flashcards

MSK- drugs Flashcards

1
Q

MOA of NSAIDs

A

non-selective inhibitors of COX enzymes

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2
Q

first line DMARD

A

methotrexate

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3
Q

MOA of methotrexate

A

follate antagonist

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4
Q

how long before conception should methotrexate be stopped

A

3 months

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5
Q

adverse effects of methotrexate

A

leukopenia/thrombocytopenia
rash/mouth ulcers
hepatitis/cirrhosis
pneumonitis
nausea/diarrhoea

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6
Q

MOA of leflunomide

A

pyrimidine synthesis inhibitors inhibit mitochondrial enzymes

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7
Q

adverse effect of hydroxychloroquine

A

retinopathy

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8
Q

biologics used when…

A

2 failed DMARDS/2 failed NSAIDS

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9
Q

adverse effects of anti-TNF therapy

A

increased risk of infection (TB)
risk of malignancy (skin cancer)
pulmonary fibrosis, heart failure

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10
Q

MOA of corticosteroids

A

increased transcription of anti-inflammatory proteins, decreased transcription of pro-inflammatory proteins

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11
Q

adverse effects of corticosteroids

A

weight gain
skin atrophy
muscle wasting
osteoporosis
diabetes
hypertension
immunosuppression
avascular necrosis of femoral head

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12
Q

first line medication for gout

A

allopurinol

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13
Q

MOA of allopurinol

A

xanthine oxidase inhibitor

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14
Q

which drug should you not take allopurinol with

A

azathioprine

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15
Q

gout when allopurinol is not tolerated

A

febuxostat

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16
Q

first line medication in majority of patients with osteoporosis

A

oral bisphonates

17
Q

second line for majority of patients with osteoporosis

A

zeledronic acid/ desunomab

18
Q

MOA of desunomab

A

binding to RANKL

19
Q

adverse effects of desunomab

A

hypocalcaemia
eczema
cellulitis

My Flashcards Year 2 (21 decks)

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