MSK- drugs Flashcards
MOA of NSAIDs
non-selective inhibitors of COX enzymes
first line DMARD
methotrexate
MOA of methotrexate
follate antagonist
how long before conception should methotrexate be stopped
3 months
adverse effects of methotrexate
leukopenia/thrombocytopenia
rash/mouth ulcers
hepatitis/cirrhosis
pneumonitis
nausea/diarrhoea
MOA of leflunomide
pyrimidine synthesis inhibitors inhibit mitochondrial enzymes
adverse effect of hydroxychloroquine
retinopathy
biologics used when…
2 failed DMARDS/2 failed NSAIDS
adverse effects of anti-TNF therapy
increased risk of infection (TB)
risk of malignancy (skin cancer)
pulmonary fibrosis, heart failure
MOA of corticosteroids
increased transcription of anti-inflammatory proteins, decreased transcription of pro-inflammatory proteins
adverse effects of corticosteroids
weight gain
skin atrophy
muscle wasting
osteoporosis
diabetes
hypertension
immunosuppression
avascular necrosis of femoral head
first line medication for gout
allopurinol
MOA of allopurinol
xanthine oxidase inhibitor
which drug should you not take allopurinol with
azathioprine
gout when allopurinol is not tolerated
febuxostat
first line medication in majority of patients with osteoporosis
oral bisphonates
second line for majority of patients with osteoporosis
zeledronic acid/ desunomab
MOA of desunomab
binding to RANKL
adverse effects of desunomab
hypocalcaemia
eczema
cellulitis
what should methotrexate be co-prescribed with to reduce side effects
5mg folic acid- once weekly on different day to methotrexate
how often should methotrexate be taken
once weekly
what drug should you avoid taking when taking methotrexate
trimethoprim
when are NSAIDs contradicted
peptic ulcer disease
consider treatment with bisphosphonates in patients with osteoperosis when T score is
</= -2.5
