MSK- rheumatoid arthritis

Question 1

swan neck deformity

Answer 1

PIP hyperextension and DIP flexion

Question 2

Boutonniere deformity

Answer 2

PIP flexion and DIP hyperextension

Question 3

Bouchard’s nodes

Answer 3

bony swellings of proximal IPJ

Question 4

Feltys syndrome

Answer 4

rare autoimmune disorder characterized by the triad of:

Rheumatoid Arthritis (RA)
Splenomegaly
Neutropenia

Question 5

rheumatoid pneumoconiosis (carplan’s syndrome)

Answer 5

characterised by intrapulmonary nodules in people with rheumatoid arthritis and a known exposure to dust particles (e.g. coal [anthracite], asbestos and silica). It can cause shortness of breath

Question 6

rheumatoid arthritis most specific serological marker

Answer 6

Anti-CCP

Question 7

chronic inflammation of MCP joints in RA can result in what

Answer 7

ulnar deviation of the digits

Question 8

first line DMARD in RA

Answer 8

methotrexate

Question 9

complication of hydroxychloroquine

Answer 9

retinopathy

Question 10

how long before conception should a patient stop methotrexate

Answer 10

3 months before

Question 11

environmental triggers of RA

Answer 11

smoking and infection increase anti-CCP

Question 12

which type of hypersensitivity reaction occurs in RA

Answer 12

type IV (type III also occur)

Question 13

rheumatoid factor Ig pattern

Answer 13

igM or igA binds to Fc region of igG

Question 14

how long does early morning stiffness last in patients with RA

Answer 14

> 30 mins, improved with activity

Question 15

polyarthralgia in patients with RA most commonly in which joints

Answer 15

small joints of hands and feet (PIP, MCPs, MTPs)

Question 16

activation of which cells in RA

Answer 16

T cells

Question 17

which antibodies bind to Fc region of which antibody in RA

Answer 17

IgM/igA bind to Fc region of igG

Question 18

which score is used to measure disease severity in RA

Answer 18

DAS28 score