DNA Flashcards
DNA Pol adds nucleotides to the
3’ end
In what direction does DNA Pol extend in?
5’ to 3’
What is the first AA in polypeptide chain during translation?
Formal Meth
Describe DNA Pol I?
- Removes RNA primer
- Has exonuclease activity
What happens within the Mismatch Repair System?
There are many proteins which recognize a mismatch in the DNA and will cut the incorrect base
What comes in to remove the incorrect nucleotide?
An exonuclease
What comes in and adds a new and correct nucleotide within the Mismatch Repair System?
A DNA Pol
UV Ray Damage creates
Pyrimidine Dimers
How does UV Ray Damage create dimers?
It causes for two identical bases to stick together, getting the identical bases to stick together
Pyramidine Dimers can be fixed via
NER
How does NER work?
- Endonuclease removes dimers
- DNA Pol will come and bring correct nucleotides
- Ligase will connect everything
What is a mismatch capable of?
Distorting DNA
What happens to the Adenines in bacterial parental DNA?
Adenines will be methylated
Endogenous DNA Damages can occur due to
Reactive O2 species
Exogenous DNA Damages can occur due to
- UV Rays
- Gamma Rays
- X Rays