Amine NTs second half 2.0

Question 2

Where is the tubero-infundibular system located?

Answer 2

Hypothalamus to the pituitary gland

Question 3

What type of receptors does dopamine act at?

Answer 3

GPCRs

Question 4

What is the tubero-infundibular system involved in?

Answer 4

Endocrine function

Question 5

What is the same between dopamine and noradrenaline?

Answer 5

Their inactivation (reuptake and degradation)

Question 6

Which pathway degenerates in parkinsons?

Answer 6

Nigro-striatal pathway

Question 7

Which NT does NMDA increase?

Answer 7

5HT

Question 8

Where does 5HT arise from?

Answer 8

Raphe nuclei

Question 9

Where does 5HT project?

Answer 9

Forebrain (cerebral cortex, cerebellum), spinal cord

Question 10

what are the 5HT neurons in the spinal cord involved in?

Answer 10

pain perception and pain regulation

Question 11

5HT dysfuncion is associated with?

Answer 11

depression, sleepy, abnormal feeding

Question 12

Increased activity of 5HT systems in regard to food?

Answer 12

Loss of appetite

Question 13

Decreased activity of 5HT systems in regard to food?

Answer 13

Gain of weight

Question 14

What is tryptophan taken up via?

Answer 14

transporters

Question 15

First thing to happen to tryptophan in 5ht synthesis?

Answer 15

Conversion to 5-hydroxytryptophan

Question 16

Which enzyme catalyses the conversion of tryptophan to 5-hydroxytryptophan?

Answer 16

Tryptophan hydroxylase

Question 17

What is 5-hydroxytryptophan converted to?

Answer 17

5-hydroxytryptamine

Question 18

What enzyme catalyses the formation of 5-hydroxytryptamine

Answer 18

5-hydroxytryptophan carboxylase

Question 19

What happens to 5-hydroxytryptamine after synthesis?

Answer 19

taken up by vesicles

Question 20

Inactivation of 5ht?

Answer 20

Reuptake and degradation

Question 21

5ht degredation enzyme?

Answer 21

Monoamine oxidase

Question 22

What is unique ab 5HTs reuptake transporters?

Answer 22

They are specific to 5HT

Question 23

Where does ACh project to from the magnocellular neurons?

Answer 23

cortex/limbic system

Question 24

Types of ACh receptor?

Answer 24

Ionotropic and GPCR

Question 25

Ionotropic ACh receptor?

Answer 25

Nicotinic

Question 26

GPCR ACh receptor?

Answer 26

Muscarinic

Question 27

What functions is ACh invoved in?

Answer 27

Arousal, sleep, waking

Question 28

Initial molecule used in ACh formation?

Answer 28

Choline

Question 29

How is ACh formed?

Answer 29

Choline combines with acetyl-CoA

Question 30

enzyme catalysing ACh formation?

Answer 30

Choline acetyltransferae

Question 31

Which enzyme breakd down ACh?

Answer 31

Acetylcholineesterase

Question 32

WHat is produced as a result of ACh breakdown?

Answer 32

Free choline, acetic acid

Question 33

what is taken up after ACh degredation?

Answer 33

Free choline

Question 34

Treatment for alzheimers regarding ACh?

Answer 34

Targets acetylcholineesterase to prevent ACh degradation