Neurotransmitters III Flashcards
Which 3 NTs are in the pathway beginning w/ tyrosine?
Dopamine, adrenaline, noradrenaline
Which neurons are lost in parkinsons?
Dopaminergic
How to label a dopaminergic neuron?
Look for tyrosine hydroxylase
What is all dopamine signalling via (receptor type)?
GPCR
How is dopamine terminated?
Monoamine Oxidase (MAO)
Epinephrine synthesis pathway?
L-tyrosine–> L-DOPA–> Dopamine–> norepinephrine–> epinephrine
Enzyme for L-Tyrosine to L-DOPA?
Tyrosine hydroxylase
Enzyme for L-DOPA to dopamine?
DOPA decarboxylase
Enzyme for dopamine to norepinepherine?
Dopamine Beta-hydroxylase
Enzyme for norepinephrine to epinephrine?
Phenylethanolamine N-methyltransferase
Difference between L-DOPA and dopamine?
L-DOPA has a carboxyl group where dopamine doesnt
What is neuromelanin important in?
Control of iron
Where is neuromelanin found?
Substantia nigra
WHich neurons and where are lost first in parkinsons?
Dopaminergic neurons in the substantia nigra
What % of dopaminergic nerve terminals could be lost b4 symptomatic presentation?
70%
5HT synthesis pathway?
Tryptophan–> 5-hydroxytryptophan–> 5-hydroxytryptomine
Tryptophan to 5-hydroxytryptophan enzyme?
Tryptophan-5-hydroxylase
5-hydroxytryptophan to 5-hydroxytryptamine enzyme?
Aromatic L-amino acid decarboxylase
What are a lot of serotonin drugs aimed at?
Targeting reuptake–> less reuptake is the same as more serotonin
Where do endocanabinoids act?
CB1 cannbinid receptor
Where and how is nitric oxide generated?
Enzymatically, in synapses
Retrograde signalling?
A molecule signalling back onto the nerve terminal from the postsynaptic side
Retrograde control?
Signals produces postsynaptically signal back onto the presynaptic neuron, regulating NT release
