Amine NTs second half 1.0 Flashcards
Where is the tubero-infundibular system located?
Hypothalamus to the pituitary gland
What type of receptors does dopamine act at?
GPCRs
What is the tubero-infundibular system involved in?
Endocrine function
What is the same between dopamine and noradrenaline?
Their inactivation (reuptake and degradation)
Which pathway degenerates in parkinsons?
Nigro-striatal pathway
Which NT does NMDA increase?
5HT
Where does 5HT arise from?
Raphe nuclei
Where does 5HT project?
Forebrain (cerebral cortex, cerebellum), spinal cord
what are the 5HT neurons in the spinal cord involved in?
pain perception and pain regulation
5HT dysfuncion is associated with?
depression, sleepy, abnormal feeding
Increased activity of 5HT systems in regard to food?
Loss of appetite
Decreased activity of 5HT systems in regard to food?
Gain of weight
What is tryptophan taken up via?
transporters
First thing to happen to tryptophan in 5ht synthesis?
Conversion to 5-hydroxytryptophan
Which enzyme catalyses the conversion of tryptophan to 5-hydroxytryptophan?
Tryptophan hydroxylase
What is 5-hydroxytryptophan converted to?
5-hydroxytryptamine
What enzyme catalyses the formation of 5-hydroxytryptamine
5-hydroxytryptophan carboxylase
What happens to 5-hydroxytryptamine after synthesis?
taken up by vesicles
Inactivation of 5ht?
Reuptake and degradation
5ht degredation enzyme?
Monoamine oxidase
What is unique ab 5HTs reuptake transporters?
They are specific to 5HT
Where does ACh project to from the magnocellular neurons?
cortex/limbic system
Types of ACh receptor?
Ionotropic and GPCR
