Wilms Tumor Flashcards
1
Q
Most common malignant renal tumor in children ?
A
Wilms tumor
2
Q
Prsentation of WT ?
A
- Unilateral flank mass
- Hematuria
- HTN=Renin secretion
3
Q
Syndromic tumor example ?
A
- WAGR syndrome
- Denys Drash syndrome
- Beckwith Wiedemann Syndrome
3
Q
Composition of Wilms Tumor ?
A
- Blastema
- Immautre kidney mesenchyme
- Primitive glomeruli
- Primative tubules
- Stromsal cells
4
Q
WAGR syndrome ?
A
- Wilms tumor
- Aniridia
- Genital abnormalities
- Mental and Motor RETARDATION
5
Q
WAGR syndrome gene ?
A
WT1 TUMOR SUPPRESSOR GENE=====11p13
6
Q
Denys-Drash Syndrome ?
A
- Wilms tumor
- Renal/Glomerular disease
- Male pseudohermaphroditism
WT1 mutations
7
Q
Beckwith-Wiedemann syndrome ?
A
- Wilsm tumor
- Neonatal hypoglycemia
- Myscular hemihypertrophy
- Organimegaly
8
Q
BW-Syndrome gene ?
A
WT2 gene—- 11p15.5
IGF-2
