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USMLE-Pathology-(Pathoma+ FA+UWorld) > Chronic Leukemia -C Lymphocytic L > Flashcards

Chronic Leukemia -C Lymphocytic L Flashcards

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USMLE® Step 1 flashcards
1
Q

Chronic leukemia ?

A

Neoplastic proliferation of circulaitng lymphocytes - High WBC Count

Pathoma-56

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2
Q

CLL which cell ?

A

Neoplastic proliferation of naive B-Cell

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2
Q

Naive B-cell express which marker ?

A
  1. CD5
  2. CD20
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3
Q

Chronic leukemia types ?

A
  1. Chronic lymphocytic leukemia
  2. Hairy cell leukemia
  3. Adult T-Cell leukemia / Lymphoma
  4. Mycosis Fungoides
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3
Q

Smudge cells where ?

Histo image

A

Chronic Lymphocytic leukemia

Pathoma-57

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4
Q

CLL findings >?

A
  1. Increased lymphocytes
  2. Smudge cells in Blood smear
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5
Q

Complications of CLL ?

A
  1. HypoGammaGlobulinemia
  2. CLL - Infection - Death
  3. Autoimmune hemolytic anemia
  4. Transformation to diffuse large B-cell lymphoma = Richter Transformstion = Seen in enlarging lymph node / spleen
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5
Q

CLL + Lymph node involvement ?

A

Generalized lymphadenopathy
=Small L Lymphoma

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6
Q

Clinical features of Hairy cell leukemia ?

A
  1. Splenomegaly = Accumulation of hairy cells in red pulp
  2. Dry tap = Bone marrow aspiration - Marrow fibrosis
  3. Lymphadenopathy
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6
Q

Neoplastic proliferation of naive B cell - Hairy cytoplasmic processes ?

A

Hairy cell leukemia

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6
Q

Hairy cell leukemia positive for —————

A

Tartrate resistant acid phosphate
TRAP

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6
Q

Transformation to diffuse large B-cell lymphoma in Chronic Lymphocytic LEUKEMIA ?

A

Ritcher transformation

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7
Q

Tx of hairy cell leukemia ?

A

2-CDA
Cladribine
=Adenosine deaminase inhibitor

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8
Q

Adult T cell leukemia /Lymphoma ?

A

CD4+ T cells

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9
Q

ATL / Lymphoma association

A

HTLV-1

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10
Q

ATL / Lymphoma association OFTEN SEEN where ?

A
  1. Japan
  2. Caribbean
11
Q

Clinical features of ATL ?

A
  1. Lymphadenopathy
  2. Rash
  3. Skin infiltration
  4. Hepatosplenomegaly
  5. Lytic/Punched out bone lesion
  6. Hypercalcemia

PATHOMA-57

12
Q

Mycosis fungoides clinical features ?

A
  1. Mature CD4+ NEOPLASTIC PROLIFERATION
  2. Skin rash
  3. Plaque
  4. Nodules
13
Q

Aggregates of neoplastic cells in epidermis is ?

A

Pautrier microabscesses

14
Q

Mycosis fungoides goes to BLOOD —-

A

Sezary syndrome

15
Q

Mycosis fungoides
CLL histo ?

A

Sezary cells
Cerebriform nuclei

Pathoma-57

USMLE-Pathology-(Pathoma+ FA+UWorld) (75 decks)

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