Chronic Leukemia -C Lymphocytic L

Question 1

Chronic leukemia ?

Answer 1

Neoplastic proliferation of circulaitng lymphocytes - High WBC Count

Pathoma-56

Question 2

CLL which cell ?

Answer 2

Neoplastic proliferation of naive B-Cell

Question 2

Naive B-cell express which marker ?

Answer 2

1. CD5
2. CD20

Question 3

Chronic leukemia types ?

Answer 3

1. Chronic lymphocytic leukemia
2. Hairy cell leukemia
3. Adult T-Cell leukemia / Lymphoma
4. Mycosis Fungoides

Question 3

Smudge cells where ?

Histo image

Answer 3

Chronic Lymphocytic leukemia

Pathoma-57

Question 4

CLL findings >?

Answer 4

1. Increased lymphocytes
2. Smudge cells in Blood smear

Question 5

Complications of CLL ?

Answer 5

1. HypoGammaGlobulinemia
2. CLL - Infection - Death
3. Autoimmune hemolytic anemia
4. Transformation to diffuse large B-cell lymphoma = Richter Transformstion = Seen in enlarging lymph node / spleen

Question 5

CLL + Lymph node involvement ?

Answer 5

Generalized lymphadenopathy
=Small L Lymphoma

Question 6

Clinical features of Hairy cell leukemia ?

Answer 6

1. Splenomegaly = Accumulation of hairy cells in red pulp
2. Dry tap = Bone marrow aspiration - Marrow fibrosis
3. Lymphadenopathy

Question 6

Neoplastic proliferation of naive B cell - Hairy cytoplasmic processes ?

Answer 6

Hairy cell leukemia

Question 6

Hairy cell leukemia positive for —————

Answer 6

Tartrate resistant acid phosphate
TRAP

Question 6

Transformation to diffuse large B-cell lymphoma in Chronic Lymphocytic LEUKEMIA ?

Answer 6

Ritcher transformation

Question 7

Tx of hairy cell leukemia ?

Answer 7

2-CDA
Cladribine
=Adenosine deaminase inhibitor

Question 8

Adult T cell leukemia /Lymphoma ?

Answer 8

CD4+ T cells

Question 9

ATL / Lymphoma association

Answer 9

HTLV-1

Question 10

ATL / Lymphoma association OFTEN SEEN where ?

Answer 10

1. Japan
2. Caribbean

Question 11

Clinical features of ATL ?

Answer 11

1. Lymphadenopathy
2. Rash
3. Skin infiltration
4. Hepatosplenomegaly
5. Lytic/Punched out bone lesion
6. Hypercalcemia

PATHOMA-57

Question 12

Mycosis fungoides clinical features ?

Answer 12

1. Mature CD4+ NEOPLASTIC PROLIFERATION
2. Skin rash
3. Plaque
4. Nodules

Question 13

Aggregates of neoplastic cells in epidermis is ?

Answer 13

Pautrier microabscesses

Question 14

Mycosis fungoides goes to BLOOD —-

Answer 14

Sezary syndrome

Question 15

Mycosis fungoides
CLL histo ?

Answer 15

Sezary cells
Cerebriform nuclei

Pathoma-57