Chronic Myeloid Leukemia

Question 1

Neoplastic proliferations of mature myeloid cells specially granulocytes ?

Answer 1

Chronic myeloid leukemia

Pathoma-58

Question 2

Which Chromosomes in CML ?

Answer 2

t-(9-22) Philadelphia chromosome whuch generates BCR-ABL fusion
which in ctyrosine kinase activity

Question 3

Tx of CML ?

Answer 3

Imatinib
Blocks tyrosine kinase activity

Question 3

Which disease is common in CML ?

Answer 3

Splenomegaly

Question 4

Mutation in pluripotent stem cells leads to —–

Answer 4

1. AML 2/3
2. ALL 1/3

Question 5

CML vs Leukomoid reaction ?

Answer 5

1. CML- t(9-22)
2. CML - inc Basophills
3. CML-Leukocyte alkaline phosphatase LAP stain - (+)

all are opposite in Leukomoid Reaction

Pathomaa-58

Question 6

Leukomoid reaction other name ?

Answer 6

Reactive neutrophilic leukocytosis

Question 6

Which cell are inc in CML ?

Answer 6

Basophills