Ovarian Tumors Flashcards
Ovarianc cell types ?
- Surface epithelium
- Germ cells
- Sex cord storma
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SECa derived from /
Coelomic epithelium
Most common type ovarian cancer ?
Surafce epithelium cancer
Lining of ovary ?
Coelomic epithelium
Benign tumor of surface peithelium cancer of ovary >???
Cystadenoma
Cystadenoma common in —
Premanopausal women
Coelomic epithelium derivatives ?
- Fallopian tube-Serous cell
- Endometrium
- Endocervix
- Mucinous cells
Common subtypes of ovarian surface epithelial cancer ?
- Serous tumor =Watery fluid
- Mucinous tumor = Mucus like fluid
Cystadenoma cyst type >
Single + Flat + Simple
Malignant tumor of surface epithelium of ovary ?
Cystadenocarcinoma
Cystadenocarcinoma common in -
Postmenopausal womnen
Cystadenocarcinoma cyst type-
Complex cyst
Shaggy lining
Which mutation ?
BRCA1
BRCA1 carrier have –
Prophylactic salpingo-oophorectomy + prophylactic mastectomy
Less common subtypes of surface epithelium ovarian cancer ?
- Endometroid tumor
- Brenner tumors
Bladder like epithelium Ca + Benign = ?
Brenner tumors
Brenner tumor Histo ?
Coffee bean nuclei on biopsy
Cystic teratoma fetal tissue ?
skin hair bone cartilage gut thyroid
Serum marker for ovarian cancer ?
CA-125
Presentation of surface epithelium ovarian cancer ?
- Vague abdominal symptoms
- Pain
- Fullness
- Sign of compression
- Urinary frequency
2nd most common ovarian cancer is –
Germ cell tumors
Tumor subtypes mimic tissues normally produced by germ cells —-
- Fetal tissue = Cystic teratoma
- Oocytes = Dysgerminoma
- Yolk sac = Endodermal sinus tumor
- Placental tissue = Choriocarcinoma
Cystic teratoma + Thyroid tissue = ?
Struma ovarii
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Fried egg appearance in Histo ?
Dysgerminoma
Dysgerminoma testicular counterpoint ?
Seminoma
Indication of Dysgerminoma ?
inc LDH
Dysgerminoma composed of —
- Large cells
- Clear cytoplasm
- Central nuclei= Represents oocytes
Placental tissue germ cell ovarian cancer name ?
Choriocarcinoma
Malignant tumor that mimic yolk sac is –
Endodermal sinus tumor
Histology of endodermal sinus tumor ?
Schiller duval bodies
EST indication ?
inc serum AFP
Choriocarcinoma composed of -
- Cytotrophoblasts
2.Syncytiotrophoblasts
Hematogenous spread tumor ?
Choriocarcinoma
Beta HCG produced by –
Syncytriotrophoblasts
Malignant tumor composed of large primitive cells-
Embryonal carcinoma
Choriocarcinoma indication ?
inc Beta-HCG
Neoplastic proliferation of granulosa and theca cell ==
G-theca cell tumor =Maliganant
Features of sex cord stromal tumors ?
- Prior to puberty
- Precocious puberty
- Menorrhagia
- Metrorrhagia
- Postmenopause -most common
- Endometrial hyperplasia with
Histo of granulosa theca cell sex cordnstromal tumor = ?
Call exner bodies
=Cell sourrounding bodies filled with pink material
Reinke crystals ?
Sertoli leydig cell tumor
Benign tumor of fibroblasts=n?
Fibroma
Association of fibroma ?
- Pleural effusion
- Ascites
- Meigs syndrome
Fate of sertoli leydig cell tumor ?
- Androgen inc
- Hiruitism
- Virilization
Krukenberg tumor ?
Metastatic mucinous tumor that involves both ovaries
Krukenberg tumor association ?
Metastatic gastric carcinoma - diffuse type
Mucinous tumor of the appendix - metastasis to ovary = ?
Pseudomyxoma peritonei
Mucus in the peritoneum
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